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ORIGINAL ARTICLE
Year : 2013  |  Volume : 6  |  Issue : 1  |  Page : 100-104

Extrapulmonary tuberculosis and HIV coinfection in patients treated for tuberculosis at the Douala General Hospital in Cameroon


1 Department of Internal Medicine, Douala General Hospital, Douala; Department of Infectious Diseases and Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon
2 Department of Internal Medicine, Douala General Hospital, Douala; Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaoundé, Cameroon
3 Department of Internal Medicine, Douala General Hospital; Department of Medicine, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon
4 Department of Internal Medicine, Douala General Hospital, Douala, Cameroon
5 Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé; Department of Internal Medicine, Jamot Hospital, Yaoundé, Cameroon

Correspondence Address:
Luma Henry Namme
Department of Internal Medicine, P. O. Box 4856, Douala
Cameroon
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.115207

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Context: Human immunodeficiency virus (HIV) infection and resulting immune depression are associated with increase proportions of extrapulmonary tuberculosis (EPTB). The prevalence of EPTB varies across studies between 15 and 50% and depends on the region, ethnic group studied, and HIV coinfection rates. In Cameroon, no studies have been done so far to evaluate the magnitude of this form of tuberculosis (TB), the various sites involved, and their association with HIV infection. Aims: To determine the prevalence of EPTB, the various organ sites affected and their association with HIV infection in a population of patients treated for TB. Settings and Design: We did cross-sectional analysis of the data from the TB register of the Douala General Hospital, a tertiary health institution situated in Douala, Cameroon. All cases of TB diagnosed between 1 st July 2007 and 30 th June 2011 were included. Results: Of total of 749 patients recorded for anti-TB treatment, the overall prevalence of HIV was 41.5% (95% confidence interval [CI]38-45.1). The prevalence of EPTB was 42.9% (321). HIV infection was present in 33.6% of patients with EPTB. The most affected sites of disease were bones and joints (29.6%), lymph nodes (17.8%), the pleura (15%), peritoneum (14.3%), and the central nervous system and meninges (9%). Neuromeningeal TB however, less common was most strongly associated with HIV infection, odd ratio (OR)2.3 (95% CI 1.1-5.0, p < 0.05). Conclusions: The proportion of EPTB among TB patients treated in the Douala General Hospital is relatively high with bone and joints being the most affected sites. HIV infection is most strongly associated with neuromeningeal forms.


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