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Year : 2014  |  Volume : 7  |  Issue : 2  |  Page : 151-152
CNS hemorrhage as clinical manifestation of dengue

1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Hainan, China

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Date of Web Publication8-Dec-2014

How to cite this article:
Joob B, Wiwanitkit V, Err H. CNS hemorrhage as clinical manifestation of dengue. Ann Trop Med Public Health 2014;7:151-2

How to cite this URL:
Joob B, Wiwanitkit V, Err H. CNS hemorrhage as clinical manifestation of dengue. Ann Trop Med Public Health [serial online] 2014 [cited 2020 Feb 19];7:151-2. Available from:
Dear Sir,

Dengue is an important tropical infection. Hemorrhage is an important clinical problem in the course of dengue infection. Hemorrhage can manifest at any organs. Brain hemorrhage in dengue is very interesting. In fact, the involvement of brain in dengue is possible and usually forgotten. It is the emerging concern in management of dengue. Brain hemorrhage is included in expanded dengue syndrome. [1],[2] The profound thrombocytopenia is mentioned as the cause of brain hemorrhage and the spontaneous resolution when dengue illness is improved can be expected. [1],[2] Kumar et al., noted that this condition has to be kept in mind "in those patients who are disoriented and have altered sensorium". [3] However, the occurrence of brain hemorrhage in the case with dengue shock can be serious and leads to death. [4] The occurrence of brainstem hemorrhage can be a very serious fatal situation. [5] Focusing on fatal dengue cases, the brain hemorrhage is a common finding. [6] It is advisable that the regular evaluation of neurological signs and symptoms in any dengue patients should be done since early detection and management of the possible neurological complication can result in good outcome.

   References Top

Assir MZ, Jawa A, Ahmed HI. Expanded dengue syndrome: Subacute thyroiditis and intracerebral hemorrhage. BMC Infect Dis 2012;12:240.  Back to cited text no. 1
Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.  Back to cited text no. 2
Kumar R, Prakash O, Sharma BS. Intracranial hemorrhage in dengue fever: Management and outcome: A series of 5 cases and review of literature. Surg Neurol 2009;72:429-33.  Back to cited text no. 3
Jain N, Gutch M, Kumar V, Naik AK. A fatal combo of dengue shock syndrome with acute subdural hematoma. Neurol India 2012; 60:105-6.  Back to cited text no. 4
[PUBMED]  Medknow Journal  
Singh M, Garg K, Bisht A, Sharma BS, Singh PK, Pandia M, et al. Spinal epidural hematoma with myelitis and brainstem hemorrhage: An unusual complication of dengue fever. Neurol India 2013; 61:541-3.  Back to cited text no. 5
[PUBMED]  Medknow Journal  
Wiwanitkit V. Magnitude and pattern of neurological pathology in fatal dengue hemorrhagic fever: A summary of Thai cases. Neuropathology 2005;25:398.  Back to cited text no. 6

Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok, Thailand

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.146455

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