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Table of Contents   
LETTER TO THE EDITOR  
Year : 2014  |  Volume : 7  |  Issue : 3  |  Page : 192-193
Effect of gold nanoparticle solution on cryptosporidium oocyst: The world first report


1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Hainan Medical University, Haikou, China; Joseph Ayo Babalola University, Ikeji-Arakeji, Osun state, Nigeria; University of Nis, Niš, Serbia

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Date of Web Publication16-Jan-2015
 

How to cite this article:
Joob B, Wiwanitkit V. Effect of gold nanoparticle solution on cryptosporidium oocyst: The world first report. Ann Trop Med Public Health 2014;7:192-3

How to cite this URL:
Joob B, Wiwanitkit V. Effect of gold nanoparticle solution on cryptosporidium oocyst: The world first report. Ann Trop Med Public Health [serial online] 2014 [cited 2019 Sep 19];7:192-3. Available from: http://www.atmph.org/text.asp?2014/7/3/192/149506
Sir,

The usefulness of gold nanoparticle solution as an anti-infective agent is widely discussed. [1] The application in development of new antibacterial drug is mentioned. [1] However, the knowledge of its activity against pathogenic protozoa is limited. Here, the authors perform a preliminary study to assess the effect of gold nanoparticle solution on cryptosporidium oocyst. The authors use the model to assess the effect of gold nanoparticle on cells as previously published papers. [2],[3],[4] Briefly, the author used the confirmed 30 stool samples containing cryptosporidium oocyst for testing. Each stool sample was divided into two parts; naïve manipulation and mixed with 1 cc of gold nanoparticle solution (the solution is prepared as the methods described in the previous study). [2],[3],[4] The authors compared the change of cryptosporidium oocyst count in each group. At the start, the average of the mean cryptosporidium oocyst number per high power field (HPF) was equal to 8.8 ± 1.2 occysts/HPF. The reduction of the mean cryptosporidium oocyst number after test could be observed. The average change after manipulation in naοve and gold nanoparticle solution mixed group equal to 1.2 ± 0.5 occysts/HPF and 4.7 ± 1.2 occysts/HPF., respectively. There is a significant difference in change between two groups (P < 0.05; t-test). This preliminary report might imply that gold nanoparticle solution has the effect against cryptosporidium oocyst. This can confirm the concept that attaching gold nanoparticle to indinavir might help increase its in vitro efficacy against Cryptosporidium parvum. [5] This is the world first report on the antiprotozoal activity of gold nanoparticle.

 
   References Top

1.
Zhao Y, Jiang X. Multiple strategies to activate gold nanoparticles as antibiotics. Nanoscale 2013;5:8340-50.  Back to cited text no. 1
    
2.
Wiwanitkit V, Sereemaspun A, Rojanathanes R. Effect of gold nanoparticle on the microscopic morphology of white blood cell. Cytopathology 2009;20:109-10.  Back to cited text no. 2
    
3.
Wiwanitkit V, Sereemaspun A, Rojanathanes R. Effect of gold nanoparticles on spermatozoa: The first world report. Fertil Steril 2009;91:e7-8.  Back to cited text no. 3
    
4.
Sereemaspun A, Rojanathanes R, Wiwanitkit V. Effect of gold nanoparticle on renal cell: An implication for exposure risk. Ren Fail 2008;30:323-5.  Back to cited text no. 4
    
5.
Bondioli L, Ludovisi A, Tosi G, Ruozi B, Forni F, Pozio E, et al. The loading of labelled antibody-engineered nanoparticles with Indinsavir increases its in vitro efficacy against Cryptosporidium parvum. Parasitology 2011;138:1384-91.  Back to cited text no. 5
    

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Correspondence Address:
Buey Joob
Sanitation 1 Medical Academic Center, Bangkok, Thailand

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.149506

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