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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 3  |  Page : 721-725

Comparison of the effects of propofol and dexmedetomidine on controlled hypotension and bleeding during endoscopic sinus surgery


1 Department of Anesthesiology, Arak University of Medical Sciences, Arak, Iran
2 Department of Rhinology and Ear Surgery, Arak University of Medical Sciences, Arak, Iran

Correspondence Address:
Hesameddin Modir
Department of Anesthesiology, Arak University of Medical Sciences, Arak
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_264_17

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Introduction: Due to the nature of the space that endoscopic sinus surgery is performed in it, even a small amount of bleeding has a negative effect on surgeon vision. The aim of this study was to compare the effects of propofol and dexmedetomidine on controlled hypotension and bleeding during endoscopic sinus surgery. Materials and Methods: In this randomized clinical trial, 100 patients candidate for endoscopic sinus surgery entered the study. The patients were randomly divided into two groups. In the first group, Group D, 1 μg/kg dexmedetomidine was injected within 10 min as the initial dose and 0.4–0.8 μg/kg/h infusion was continued. In Group P, 50–150 μg/kg/min Propofol was infused. Hemodynamic parameters were measured from the onset of the study to 120 min after surgery, and the intraoperative bleeding was reported by surgeon. Results: Mean score of bleeding was 1.14 ± 0.70 in Group D and 1.24 ± 0.74 in Group P (P = 0.490). Wilks' group Lambda test showed a significant reduction in heart rate of both groups (F = 3.45, P = 0.002). Heart rate in Group P was significantly lower than Group D (Greenhouse-Geisser test, F = 2.70, P = 0.015). There was no statistical difference in mean arterial pressure and O2saturation. The average time of patients recovery was 32.52 ± 7.9 min in Group D and 29.90 ± 10.6 min in Group P (P = 0.166). Conclusion: Propofol could reduce heart rate significantly more than dexmedetomidine. However, about reduction of bleeding and obtaining an appropriate surgical field which were the main outcomes of the study, there was no significant difference between groups.


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