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Table of Contents   
LETTER TO THE EDITOR  
Year : 2017  |  Volume : 10  |  Issue : 4  |  Page : 1074
Structure of nonstructural protein 1 of dengue and Zika virus: Difference and implication for pathogenesis and vaccine development


1 Sanitation1 Medical Academic Center, Bangkok, Thailand
2 Hainan Medical University, Hainan, China

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Date of Web Publication5-Oct-2017
 

How to cite this article:
Joob B, Wiwanitkit V. Structure of nonstructural protein 1 of dengue and Zika virus: Difference and implication for pathogenesis and vaccine development. Ann Trop Med Public Health 2017;10:1074

How to cite this URL:
Joob B, Wiwanitkit V. Structure of nonstructural protein 1 of dengue and Zika virus: Difference and implication for pathogenesis and vaccine development. Ann Trop Med Public Health [serial online] 2017 [cited 2019 Sep 19];10:1074. Available from: http://www.atmph.org/text.asp?2017/10/4/1074/196675


Dear Editor,

Arboviral diseases are important group of tropical infection, which is present global public health issue. Zika virus and dengue virus are the two well-known arbovirus, which cause emerging and remerging infections around the world in the present day.[1] To combat with these diseases, the only available method at present is mosquito control, which is usually ineffective. To find the new drug and vaccine is the hope but it is still not successful. To learn the structure of the viruses can be useful information for understanding pathogenesis and further drug and vaccine development. Nonstructural protein 1 (NS1) of the arbovirus is the focused protein for researching. Here, the authors discusses on the findings on structure of NS1 of dengue and Zika virus. Of interest, the sequences of proteins from both viruses are totally different; hence, it is no doubt that the structures of the NS1s from both viruses are different. The recent report also confirmed the different electrostatic property of NS1 of dengue and Zika viruses.[2] This can confirm that dengue and Zika viruses have different NS1-related biological processes and pathogeneses. Also, this cannot support the idea of developing new single vaccine to target at common NS1 of Zika and dengue viruses.

Acknowledgements

None.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Choumet V, Desprès P. Dengue and other flavivirus infections. Rev Sci Tech 2015;34:473-8,467-72.  Back to cited text no. 1
    
2.
Song H, Qi J, Haywood J, Shi Y, Gao GF. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses. Nat Struct Mol Biol 2016;23:456-8.  Back to cited text no. 2
    

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Correspondence Address:
Beuy Joob
Sanitation1 Medical Academic Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.196675

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