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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1529-1532

Genetic polymorphism of glutathione S-transferase A1 promoter in patient with colorectal cancer


1 Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Mycology and Parasitology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Naser Nazari
Department of Mycology and Parasitology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_494_17

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Background: Novel allelic variants have been found in the glutathione S-transferase(GST) A1 gene. The former GSTA1 B allele is associated with low expression. Objective: The aim of this study was to determine the GSTA1 genotype in the Iranian patient with colorectal cancer and determine if there is any populational correlation between genotype and colorectal cancer in Kermanshah-Iran and Tehran-Iran individuals. Material and Methods: Atotal of 186 participants were included in the study, 52 Tehranian and 41 Kermanshahian patients with colorectal cancer, plus 52 Tehranian and 41 Kermanshahian healthy controls. GSTA1 genotype was determined by polymerase chain reaction-restriction fragment length polymorphism. Differences in genotype distributions between the different populational groups were evaluated us in Chi-squared test and a logistic regression was used to investigate the possible association of the genotypes with the disease in both populations. Odds ratio estimates were analyzed for allele frequencies. Results: The GSTA1 B/B genotype prevalence in patients with colorectal cancer(12.2%) was significantly higher than control group in Kermanshah(0.0%), No significant association of GSTA1 B/B genotype with the colorectal cancer was determined in Tehran subjects. No significant association of GSTA1 B/A genotype with the colorectal cancer was determined either population. Conclusion: These findings indicate that the GSTA1 B/B genotype in the Kermanshah population was related to colorectal cancer although there is no significant association between of GSTA1 B/B genotype and colorectal cancer in Tehran population. This study showed different results between populations.


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