Annals of Tropical Medicine and Public Health

LETTER TO THE EDITOR
Year
: 2013  |  Volume : 6  |  Issue : 3  |  Page : 391-

Coagulation defect in the fifth species of human malaria: A topic that has never beensystematically addressed


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok, Thailand

Correspondence Address:
Viroj Wiwanitkit
Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok - 10160
Thailand




How to cite this article:
Wiwanitkit V. Coagulation defect in the fifth species of human malaria: A topic that has never beensystematically addressed.Ann Trop Med Public Health 2013;6:391-391


How to cite this URL:
Wiwanitkit V. Coagulation defect in the fifth species of human malaria: A topic that has never beensystematically addressed. Ann Trop Med Public Health [serial online] 2013 [cited 2020 Feb 20 ];6:391-391
Available from: http://www.atmph.org/text.asp?2013/6/3/391/121025


Full Text

Dear Sir,

Malaria is an important tropical infection that is accepted for its global importance. However, in the past few years, the newest fifth species of human malaria Plasmodiumknowlesi was documented. [1] From its origin in Malaysia, there have been several reports of malaria by this species in several countries worldwide. This disease is a zoonosis and can be easily misdiagnosed as P. malariae infection. [1] Apart from the acute febrile presentation, an importantpathological condition of the fifth species malaria, which is rarely mentioned, is the disturbanceof coagulation. Indeed, it has been confirmed that P. knowlesi malaria can induce coagulopathy in animals.

In a simian model, "the occurrence of intravascular coagulation during the last 48hours of the disease, concurrent with a marked fall in hematocrit levels" has been reported. [2]" However, there isonly one observational report on human infection. [3] Daneshvar et al. studied 107 humanP. knowlesi malaria cases and found that "all were thrombocytopenic at hospital admission or onthe following day. [3]" However, there is no explanation for the pathomechanismof this finding. Also, there is no systematical assessment on the effect of P. knowlesi malaria infection in humans. Hence, it is the topic for further study on coagulation change in human P. knowlesi malaria.

References

1Sabbatani S, Fiorino S, Manfredi R. The emerging of the fifth malaria parasite (Plasmodium knowlesi): A public health concern? Braz J Infect Dis 2010;14:299-309.
2Abildgaard C, Harrison J, DeNardo S, Spangler W, Gribble D. Simian Plasmodium knowlesi malaria: Studies of coagulation and pathology. Am J Trop Med Hyg 1975;24:764-8.
3Daneshvar C, Davis TM, Cox-Singh J, Rafa'ee MZ, Zakaria SK, Divis PC. Clinical and laboratory features of human Plasmodium knowlesi infection.Clin Infect Dis 2009;49:852-60.