Annals of Tropical Medicine and Public Health

LETTER TO THE EDITOR
Year
: 2015  |  Volume : 8  |  Issue : 3  |  Page : 75-

Cutaneous hypersensitivity in dengue infection and explanation of its pathogenesis by allergenicity assessment


Viroj Wiwanitkit 
 Hainan Medical University, Hainan, China

Correspondence Address:
Prof. Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok
China




How to cite this article:
Wiwanitkit V. Cutaneous hypersensitivity in dengue infection and explanation of its pathogenesis by allergenicity assessment.Ann Trop Med Public Health 2015;8:75-75


How to cite this URL:
Wiwanitkit V. Cutaneous hypersensitivity in dengue infection and explanation of its pathogenesis by allergenicity assessment. Ann Trop Med Public Health [serial online] 2015 [cited 2019 Nov 15 ];8:75-75
Available from: http://www.atmph.org/text.asp?2015/8/3/75/157643


Full Text

Dear Sir,

Dengue is an important tropical infection that can have several clinical presentations. Cutaneous hypersensitivity is an important finding that is not frequently mentioned. According to the recent report by Karoli et al., cutaneous hypersensitivity can be seen in 16% of the infected cases. [1] The question is whether the dengue virus protein can act as an allergen or not. To answer this question, the author used the standard bioinformatics allergenicity testing, EVALLER (Uppsala Biomedical Centre, Uppsala, Sweden) [2] to test the genome polyprotein of dengue virus (Accession: P29990.1). The study revealed that the genome polyprotein of dengue virus was not an allergen. However, it had close similarity to the allergen vacuolar serine protease (Penicillium chrysogenum). [3] The mentioned allergen has a strong relationship with immunoglobulin E (IgE) hypersensitivity, and this might be an explanation for cutaneous hypersensitivity in dengue. This is a topic that should be further investigated.

References

1Karoli R, Fatima J, Siddiqi Z, Kazmi KI, Sultania AR. Clinical profile of dengue infection at a teaching hospital in North India. J Infect Dev Ctries 2012;6:551-4.
2Martinez Barrio A, Soeria-Atmadja D, Nistér A, Gustafsson MG, Hammerling U, Bongcam-Rudloff E. EVALLER: A web server for in silico assessment of potential protein allergenicity. Nucleic Acids Res 2007;35:W694-700.
3Shen HD, Chou H, Tam MF, Chang CY, Lai HY, Wang SR. Molecular and immunological characterization of Pen ch 18, the vacuolar serine protease major allergen of Penicillium chrysogenum. Allergy 2003;58:993-1002.