Annals of Tropical Medicine and Public Health

: 2016  |  Volume : 9  |  Issue : 5  |  Page : 340--343

Artesunate-induced hemoglobinuria in falciparum malaria

Avik Karak, Biaus Samanta, Rashi Maheshwari, Arunansu Talukdar 
 Department of General Medicine, Medical College, Kolkata, West Bengal, India

Correspondence Address:
Arunansu Talukdar
Department of General Medicine, Medical College, 88, College Street, Kolkata - 700 073, West Bengal

A 26-year-old male got admitted with fever of 103°F with chills and rigor for 6 days. He was diagnosed with Plasmodium falciparum infection by peripheral blood smear examination, later confirmed by polymerase chain reaction analysis. Blood smear showed 2% parasitemia. As the patient was hypotensive, intravenous artesunate was started. Two days later, he reported passing źDQ╗Coca-ColaźDQ╗-colored urine. Examination revealed tachycardia, anemia, and mild icterus. Serum free hemoglobin and lactate dehydrogenase was elevated whereas haptoglobin was very low. Urine showed the presence of hemoglobin without red blood cells. Glucose-6-phosphate dehydrogenase assay was normal. Chloroquine, primaquine, and quinine levels in blood were undetectable. There was no evidence of any coinfection. Artesunate was stopped suspecting a causal relationship. Intravenous quinine was started. The urine showed progressive clearance over 3 days, and the patient recovered. The strong temporal association of initiating artesunate and occurrence of hemoglobinuria suggested the possible etiological implication which is not documented before.

How to cite this article:
Karak A, Samanta B, Maheshwari R, Talukdar A. Artesunate-induced hemoglobinuria in falciparum malaria.Ann Trop Med Public Health 2016;9:340-343

How to cite this URL:
Karak A, Samanta B, Maheshwari R, Talukdar A. Artesunate-induced hemoglobinuria in falciparum malaria. Ann Trop Med Public Health [serial online] 2016 [cited 2020 Jan 28 ];9:340-343
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