Annals of Tropical Medicine and Public Health

LETTER TO THE EDITOR
Year
: 2016  |  Volume : 9  |  Issue : 6  |  Page : 402--403

Adding NS1 antigen test to IgM/IgG test for dengue diagnosis: Cost utility analysis


Sora Yasri1, Viroj Wiwanitkit2,  
1 KMT Primary Care Center, Bangkok, Thailand
2 Joseph Ayo Babalola University, Nigeria

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok
Thailand




How to cite this article:
Yasri S, Wiwanitkit V. Adding NS1 antigen test to IgM/IgG test for dengue diagnosis: Cost utility analysis.Ann Trop Med Public Health 2016;9:402-403


How to cite this URL:
Yasri S, Wiwanitkit V. Adding NS1 antigen test to IgM/IgG test for dengue diagnosis: Cost utility analysis. Ann Trop Med Public Health [serial online] 2016 [cited 2019 Sep 22 ];9:402-403
Available from: http://www.atmph.org/text.asp?2016/9/6/402/193937


Full Text

Dear Sir,

Dengue is a common mosquito borne infection that is still the global public health threat. There are many cases of fatalities due to dengue in outbreaks each year. The diagnosis of dengue can be problematic due to the fact that there are many similar infections.[1] At present, the use of dengue IgM/IgG serological test has become a useful tool for helping to definitively diagnose dengue.[2] However, there are also cases of dengue that visit to the physician before there is any evidence of immunity response to be diagnosed by serological test. The new NS1 antigen test is introduced for those cases.[3] However, the important concern of using any new test in clinical pathology is the cost. Here, the authors perform cost-utility analysis for adding NS1 antigen test to IgM/IgG test for dengue diagnosis. Data from 184 laboratory diagnoses of dengue in our laboratory during its outbreak in October 2015 was analyzed. In this assessment, the cost is the charge for the test in US (local currency, Thai Baht, 1 US dollar = 34 Thai Bath). The utility is the diagnostic rate of dengue. The cost utility in this work is the cost per dengue case diagnosis. The results are shown in [Table 1]. It seems that the cost per diagnosis for combining NS1 to IgM/IgG is higher. Although adding the NS1 antigen test to IgM/IgG test can help detect more cases, it costs more and seems based on medical economics concern.{Table 1}

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Conflicts of interest

There are no conflicts of interest.

References

1Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.
2Tang KF, Ooi EE. Diagnosis of dengue: An update. Expert Rev Anti Infect Ther 2012;10:895-907.
3Muller DA, Young PR. The flavi virus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Res 2013;98:192-208.