Annals of Tropical Medicine and Public Health

LETTER TO THE EDITOR
Year
: 2017  |  Volume : 10  |  Issue : 1  |  Page : 287-

Higher incidence of cholangiocarcinoma among males than females: Is there any explanation?


Won Sriwijitralai1, Viroj Wiwanitkit2,  
1 RV Medical Center, Bangkok, Thailand
2 Hainan Medical University, Haikou, China

Correspondence Address:
Dr. Won Sriwijitralai
RV Medical Center, Bangkok
Thailand




How to cite this article:
Sriwijitralai W, Wiwanitkit V. Higher incidence of cholangiocarcinoma among males than females: Is there any explanation?.Ann Trop Med Public Health 2017;10:287-287


How to cite this URL:
Sriwijitralai W, Wiwanitkit V. Higher incidence of cholangiocarcinoma among males than females: Is there any explanation?. Ann Trop Med Public Health [serial online] 2017 [cited 2020 Jul 6 ];10:287-287
Available from: http://www.atmph.org/text.asp?2017/10/1/287/205578


Full Text

Dear Sir,

Cholangiocarcinoma (CCA) is the specific cancer of bile duct that is very highly prevalent in tropical Southeast Asia. There is an interesting issue of sexual preference of this cancerous disease. The recent report by Mosadeghi et al. is very interesting.[1] Mosadeghi et al. mentioned the “sex-specific and race/ethnicity-specific disparities in CCA incidence.”[1] Mosadeghi et al. noted that “overall, CCA incidence was higher among men compared to women.”[1] In fact, this trend can be seen around the world. The interesting question is that whether there is any explanation. In the endemic area, Southeast Asia, the main risk bahavior of CCA is the “raw fish intake,” which is very common among the local people (either male or female). Focusing on the recent finding, the parasitic metabolite, estrogen-like substance, is mentioned for its important role in carcinogenesis.[2] Mancino et al. mentioned that “estrogens stimulate the proliferation of human CCA by inducing the expression and secretion of vascular endothelial growth factor.”[3] Physiologically, estrogen is a female hormone and females have the mechanism for the uptake and use of estrogen. This situation is different from males and this might be a possible explanation as to why there is a higher incidence of CCA among males than females.

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Conflicts of interest

There are no conflicts of interest.

References

1Mosadeghi S, Liu B, Bhuket T, Wong RJ. Sex-specific and race/ethnicity-specific disparities in cholangiocarcinoma incidence and prevalence in the U.S.: An updated analysis of the 2000-2011 surveillance, epidemiology, and end results registry. Hepatol Res 2015. [Epub ahead of print].
2Brindley PJ, da Costa JM, Sripa B. Why does infection with some helminths cause cancer? Trends Cancer 2015;1:174-82.
3Mancino A, Mancino MG, Glaser SS, Alpini G, Bolognese A, Izzo L, et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis 2009;41:156-63.