Annals of Tropical Medicine and Public Health

: 2017  |  Volume : 10  |  Issue : 2  |  Page : 484--485

Zika virus infection, blood glucose, and diabetes mellitus

Somsri Wiwanitkit1, Viroj Wiwanitkit2,  
1 Wiwanitkit House, Bangkhae, Bangkok, Thailand
2 Faculty of Medicine, University of Nis, Serbia, Europe; Hainan Medical University, Hainan, China

Correspondence Address:
Somsri Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok

How to cite this article:
Wiwanitkit S, Wiwanitkit V. Zika virus infection, blood glucose, and diabetes mellitus.Ann Trop Med Public Health 2017;10:484-485

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Zika virus infection, blood glucose, and diabetes mellitus. Ann Trop Med Public Health [serial online] 2017 [cited 2020 Jul 13 ];10:484-485
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Full Text

Dear Sir,

The Zika virus infection becomes the present big health problem. This acute hemorrhagic viral illness can cause dengue-like infection and induce fetal abnormality.[1],[2] WHO already declared for public health importance of this new disease.[3] The interesting concern in endocrinology is the effect of Zika virus in diabetes mellitus. To the best of our knowledge, there are still a few reports on this topic. However, there are some reports mentioning for the blood glucose test among the infected cases. It is reported that the blood glucose in the infected cases is within normal limit.[4] There is also a recent report showing that there is no pancreas abnormality from an imaging study in the infected case.[4] In addition to general clinical information, the autopsy report also confirmed no virus detection in the pancreas.[5] However, an interesting published data on Zika virus infection case with encephalitis showed normal blood glucose but have increased CSF to blood glucose ratio, which is different from general viral encephalitis.[6] Finally, as already noted, the Zika virus infection is a dengue-like infection. For dengue, it is proved that the dengue virus can induce pancreas problem and result in diabetes.[7] It is also proved that dengue virus can induce glycolysis during its infection which is a direct pathological problem on glucose metabolism.[8] The similar phenomenon in Zika virus infection should be looked for.

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1Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health 2015;8:145-6.
2Wiwanitkit S, Wiwanitkit V. Acute viral hemorrhage disease: A summary on new viruses. J Acute Dis 2015;4:277-9.
3Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ 2016;352:i657.
4Deng Y, Zeng L, Bao W, Xu P, Zhong G. Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2016;28:106-9.
5Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, et al. Zika virus infection and stillbirths: A case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl Trop Dis 2016;10:e0004517.
6Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med 2016;374:1595-6.
7Lee IK, Khor BS, Kee KM, Yang KD, Liu JW. Hyperlipasemia/pancreatitis in adults with dengue hemorrhagic fever. Pancreas 2007;35:381-2.
8Fontaine KA, Sanchez EL, Camarda R, Lagunoff M. Dengue virus induces and requires glycolysis for optimal replication. J Virol 2015;89:2358-66.