Annals of Tropical Medicine and Public Health

: 2017  |  Volume : 10  |  Issue : 3  |  Page : 755--756

Prenatal MRI in Zika Virus Infection

Viroj Wiwanitkit 
 Visiting professor Hainan Medical University, China; Wiwanitkit House, Bangkhae, Bangkok, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok

How to cite this article:
Wiwanitkit V. Prenatal MRI in Zika Virus Infection.Ann Trop Med Public Health 2017;10:755-756

How to cite this URL:
Wiwanitkit V. Prenatal MRI in Zika Virus Infection. Ann Trop Med Public Health [serial online] 2017 [cited 2020 Sep 25 ];10:755-756
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Dear Editor,

The prenatal diagnosis of brain abnormality due to Zika virus infection is an interesting issue in tropical medicine. The recent report by Guillemette-Artur et al.[1] on “prenatal brain MRI of fetuses with Zika virus infection” is very interesting. Guillemette-Artur et al.[1] found that “severe cerebral damage was observed in our series, with indirect findings suggesting that the germinal matrix is the principal target for Zika virus..” In fact, this finding is contrast to some previous reports. In a recent report by Cavalheiro et al.[2], it is noted that “there is a definitive pathognomonic radiographic pattern of microcephaly caused by Zika virus.” In addition, as noted by Guillemette-Artur et al.[1], the similar findings to that can be seen in cytomegalovirus infection is mentioned Indeed, the similarity can be expected, as both Zika virus and cytomegalovirus (CMV) can directly attack fetal brain tissue. However, there is an interesting observation, “gross” calcifications, that is not commonly observed in cases with cytomegalovirus infection.[3] In fact, although both Zika virus and CMV attack fetal brain tissue, accounting for similarities being expected regarding brain lesions, there might be argument. Parvovirus B19 and Toxoplasmosis also attack fetal brain tissue but are responsible for very different lesions due to mechanism being different. In CMV, gross or more subtle calcifications can be observed. Saying that the germinal matrix might be the principal target for Zika virus is not at all in contradiction with other reports and this hypothesis should be confirmed by further experiments.

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1Guillemette-Artur P, Besnard M, Eyrolle-Guignot D, Jouannic JM, Garel C. Prenatal brain MRI of fetuses with Zika virus infection. Pediatr Radiol 2016;46:(7)1032-9.
2Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MD, Moron A, Lederman HM. Microcephaly and Zika virus: neonatal neuroradiological aspects. Childs Nerv Syst 2016;32:(6)1057-60.
3Malinger G, Lev D, Lerman-Sagie T. Imaging of fetal cytomegalovirus infection. Fetal Diagn Ther 2011;29:117-26.