LETTER TO THE EDITOR
Year : 2017 | Volume
: 10 | Issue : 6 | Page : 1842--1843
Fast mutation rate of Zika virus: Observation in sequences in Asian lineage isolated from Southeast Asian countries
Somsri Wiwanitkit1, Viroj Wiwanitit2,
1 Wiwanitkit House, Bangkhae, Bangkok, Thailand
2 Hainan Medical University, Hainan, China
Wiwanitkit House, Bangkhae, Bangkok
|How to cite this article:|
Wiwanitkit S, Wiwanitit V. Fast mutation rate of Zika virus: Observation in sequences in Asian lineage isolated from Southeast Asian countries.Ann Trop Med Public Health 2017;10:1842-1843
|How to cite this URL:|
Wiwanitkit S, Wiwanitit V. Fast mutation rate of Zika virus: Observation in sequences in Asian lineage isolated from Southeast Asian countries. Ann Trop Med Public Health [serial online] 2017 [cited 2019 Aug 22 ];10:1842-1843
Available from: http://www.atmph.org/text.asp?2017/10/6/1842/222648
The mutation within the new emerging viral pathogen is usually the important public health concern. Focusing on the Zika virus infection, “the suggested rate of 12 to 25 mutations a year” was recently reported. Since Zika virus sequences has 10,807 bp, the difference among different sequences identified in 1-year interval should not be more than 0.23%, or it means that the magnitude of 1% might be expected in a 5-year period.
Here, the authors tried to reassess the observation in sequences in Asian lineage isolated from Southeast Asian countries. The four isolated sequences were studied (JN860885 Cambodia 2010, KM8510138 The Philippines 2012, KM851039 Thailand 2014, and KX377336 Malaysia 2016). If the already-mentioned mutation rate is correct, there should be the difference pattern according to the mentioned explanation “1% in a 5-year period.” Surprisingly, the sequence alignment showed the similarity at 0.99 between each pairs of studied sequences regardless of the year of isolation. This might imply that mutation rate that is faster than proposed previously can be observed in Southeast Asia, and the recent reports confirmed that Zika virus infection “spread independently to time and place background” in this region. Also, this confirms the need to pay attention to the Zika virus in this region.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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