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Year : 2012  |  Volume : 5  |  Issue : 4  |  Page : 295-297
Pandemic influenza A H1N1 in Iran and lessons learnt

Department of Health Policy, Health Management Research Center, Baqiyatallah (a.s) University of Medical Sciences, Tehran, Iran

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Date of Web Publication8-Oct-2012


Objective: To assess pandemic Flu A H1N1 in Iran and lessons learnt the study was performed in order to find out it's health impacts in the community. Materials and Methods: The overview is based on literature identified through a search in PubMed and on official reports from WHO and the disease control center of I.R.Iran. Findings: As of December 30, 2009, a total of 3672 confirmed cases of human infection with a novel Influenza A (2009 H1N1) virus had been reported in Iran with 140 deaths. Conclusion: Good management performed by Iranian Ministry of Health and W.H.O collaboration to reduce the mortality and morbidity related to the disease. For the next pandemic situation different guidelines for different health policy in both national and international level may be required.

Keywords: Community, health, Influeanza A H1N1, lessons learnt, pandemic flu

How to cite this article:
Tavana AM. Pandemic influenza A H1N1 in Iran and lessons learnt. Ann Trop Med Public Health 2012;5:295-7

How to cite this URL:
Tavana AM. Pandemic influenza A H1N1 in Iran and lessons learnt. Ann Trop Med Public Health [serial online] 2012 [cited 2021 Mar 9];5:295-7. Available from:

   Introduction Top

At the beginning of 21 the millennium the pandemic influenza A (H1N1) has been occurred. Between mid March and mid April 2009 a pandemic influenza A virus emerged in Mexico. [1] In June 2009, the World Health Organization declared the new strain of swine-origin H1N1 as a pandemic. The Pandemic influenza A H1N1 occurred in April 2009 in a Mexican city and quickly spread across the globe resulting in million been infected and thousands killed. The disease very quickly spread in different part of the world. It has to be said the disease has been infected million of population in different continents and killed at least 18449 persons [Table 1]. [2] The disease was appeared more severe than in many countries perhaps as result of genetic susceptibility, low immunity of individual and epidemiological and heath care availability for preventing the disease. [3],[4] the diseases were papered in Iran too as the same as other countries. As of December 30, 2009, a total of 3672 confirmed cases of human infection with a novel Influenza A (2009 H1N1) virus had been reported in Iran with 140 deaths. The WHO in 2010 (On August 10,) announced that the pandemic was over". [5] Saying worldwide influenza activity had returned to typical seasonal patterns. [6] According to World Health Organization (WHO) more than 214 countries and overseas territories or communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including over 18,449 deaths. The Aim of this study was to determine the situation of the disease during pandemic period in 2009 in Iran and lessons learnt.
Table 1: World health organization Regions and number of death related to pandemic influenza in 2009

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   Material and Methods Top

The overview is based on literature identified through a search in PubMed (using PubMed's own search strategy) and on official reports from WHO and the disease control center of I.R. Iran.

   Results Top

The new influenza A (H1N1) has infected thousand and thousands of Iranian population. Only 140 patients with different risk factors were died as result of infection.

   Discussion Top

Since the declaration of a swine influenza pandemic by the World Health Organization (WHO), the Islamic Republic of Iran has launched a surveillance system to test all suspected cases, both in community and hospital settings. And many researches have been done by Iranian researcher which is showed the situation of the disease during pandemic. Tabarsi et al. 2011 in a retrospective cross-sectional study in Iranian patients was conducted that among patients with mortality and admissions to ICU with confirmed HINI. Demographic, clinical, laboratory, radiological findings, and epidemiologic data were abstracted from medical records, using a standardized data sheet found that delayed antiviral treatment was more common among patients who died and the elderly. [6] In a study by Gholami et al. 2011, they concluded that mass media as one of the main sources of information providing the required information at the time of H1N1 pandemic for physicians. [7] Dashti-Khavidaki et al. has reported the first case of Pandemic Influenza AH1N1 referred to Imam Khomeini Hospital in Iran in intensive care unit they mentioned Oseltamivir was administered within three hours of the patient's admission. They noted that the median length of stay for hospitalized patients was 3 days. [8] The diseases have seen in different age group with different medical status. [9] Moattari et al. has been analyzed antigenic variation of human infection of the viruses by using multiplex RT-PCR and phylogenetic analysis during pandemic and they were found that The H1N1 subtypes showed a notable resemblance to A/New Caledonia/20/99 vaccine strain and therefore were predicted to be capable of conferring sufficient immunity against H1N1 subtypes. [10] Moghadami et al. mentioned two wave of pandemic Influenza in Iran. They are investigated that high seroprevalence of antibody against 2009 H1N1 in the sera (2553) of people in the south of Iran, describes either a high level of pre-existing immunity against H1N1 in Iranian population or a high rate of asymptomatic infection. [11] Jandaghi et al. 2010 reported that no genetic indication of resistance to neuraminidase inhibitors was found in their studies. Although genomic analysis of hemagglutinin and neuraminidase genes of Iranian strains in comparison to the corresponding vaccine strain revealed some mutations, none of these were identified in functionally important receptor-binding sites. [12] Haghdoost and co-worker 2010 has reported that of the cases, 75% were 5-40 years-old and the prevalence of death had no significance correlation with sex and age (P = 0.720 and 0.194, respectively). [13] In a research during pandemic a research for pandemic modeling suggested to government it is the best to provide a golden opportunity to vaccinate a considerable proportion of the population. [12] The first report of Pandemic influenza may be had different sources all most all cases had aboard sources (i.e. in Isfahan in central of Iran the first case was reported from patient who had history to travel as pilgrim came from Saudi Arabia (Mecca) based on Anahita et al. research. [5] Mogadami et al. has mentioned that high seroprevalence of antibody against 2009 H1N1 in the sera of either a high level of pre-existing immunity against H1N1 or a high rate of asymptomatic infection in Iranian population. [14] The study of knowledge, attitude and practices of health care workers to influenza infection were good in Iran during pandemic Influenza A H1N1 except in nurses that showed 'the mean knowledge score of nurses was significantly lower than that of the other groups of health workers. [15] It should be noted the most dying cases were happened in Acute respiratory death syndrome (ARDS) 81 cases (77%) and viral pneumonia with 29 cases (27%) respectively based on Gouya et al. study. [16]

   Conclusion Top

The pandemic influenza A H1N1 spread in 214 countries in the world based on W.H.O report, but the rate of mortality and morbidity was related to many factors including, preparation against the diseases, action plans policy, practice, public awareness, health care system and preparation of enough medicine and vaccine for patients. Very fortunately Iranian Government has performed the best including mobilize the heath care system and preparation of medicine particularity Ostamivar and good prescriptions of medicine in order to prevent viral resistance, regular health education to the public by encouraging the governmental and non governmental organization including Iranian Radio and TV board costing try to reduce the risk of infection. Publish much scientific and usual paper in mass media to alert physicians as well as public. [17],[18] Therefore the pandemic situation was over with at least 3672 confirmed patients and 140 deaths. We were prepared before pandemic situation and good inter-sector collaborations in National level and W.H.O. coordination reduced the mortality and morbidity of infection. I believe that for the next pandemic consideration of personnel hygiene in particular regular hand washing, take a fluid in daily diet, reduce the overcrowding as much as possible in the schools, camps, etc, good laboratory diagnosis and quick case finding and early treatment with appropriate medicine could be focused in national level. In addition, different guidelines for different health policy in international level may be required.

It should be added that, good blood supply before pandemic situation, discipline on health and hygiene in schools, day care center, may be required. Preparations in hospitals in particular in infectious diseases ward and clinics are required before pandemic start too. Non necessary travel must be omitted by W.H.O regulation in order to prevent the risk of infection in international level. In addition the travelers must be taken good attention to take care during travel and with having good knowledge the disease and consulting with General Practitioner before and after their travel.

   References Top

1.Zepeda-Lopez HM, Perea-Araujo L, Miliar-García A, Dominguez-López A, Xoconostle-Cázarez B, Lara-Padilla E, et al. Inside the outbreak of the 2009 influenza A (H1N1) virus in Mexico. PLoS One 2010;5:e13256.  Back to cited text no. 1
2.Pandemic (H1N1) 2009 - update 112 [Internet]. Geneva: World Health Organization; 2011 [updated 6 August 2010]. Available from: [accessed 7 February 2012].  Back to cited text no. 2
3.Kelly HA. A pandemic response to a disease of predominantly seasonal intensity. Med J Aust 2010;192:81-3.  Back to cited text no. 3
4.Pedroni E, Garcia M, Espinola V, Guerrero A, Gonzalez C, Olea A, et al. Chilean Task Force for study of Pandemic Influenza A (H1N1). Outbreak of 2009 pandemic influenza A (H1N1), Los Lagos, Chile, April-June 2009. Eur Surveill 2010;15:19456.  Back to cited text no. 4
5.Babak A, Akhtar E, Nobari RF, Ataei B. Surveillance on the 2009 pandemic influenza A (H1N1) virus, Isfahan, Iran. J Res Med Sci 2011;16:119.  Back to cited text no. 5
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6.Tabarsi P, Moradi A, Marjani M, Baghaei P, Hashemian SM, Nadji SA, et al. Factors associated with death or intensive care unit admission due to pandemic 2009 influenza A (H1N1) infection. Ann Thorac Med 2011;6:91-5.  Back to cited text no. 6
[PUBMED]  Medknow Journal  
7.Gholami J, Hosseini SH, Ashoorkhani M, Majdzadeh SR. Lessons learned from H1N1 epidemic: The role of mass media in informing physicians. Int J Prev Med 2011;2:32-7.  Back to cited text no. 7
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8.Dashti-Khavidaki S, Khalili H, Gholamalipour F, Soudbakhsh A, Talasaz AH, Hajabdolbaghi M, et al. Approach to Pandemic 2009 influenza: First report from a main referral hospital for Pandemic H1N1 influenza care in Iran. J Infect Dev Ctries 2010;4:629-35.  Back to cited text no. 8
9.Honarvar B, Asadi N, Ghaffarpasand F, Moghadami M, Kasraeian M. Pregnancy outcomes among patients infected with pandemic H1N1 influenza virus in Shiraz, Iran. Int J Gynaecol Obstet 2010;111:86-7.   Back to cited text no. 9
10.Moattari A, Ashrafi H, Kadivar MR, Kheiri MT, Shahidi M, Arabpour M, et al. Antigenic variations of human influenza virus in Shiraz, Iran. Indian J Med Microbiol 2010;28:114-9.  Back to cited text no. 10
[PUBMED]  Medknow Journal  
11.Gooya MM, Soroush M, Mokhtari-Azad T, Haghdoost AA, Hemati P, Moghadami M, et al. Influenza A (H1N1) pandemic in Iran: report of first confirmed cases from June to November 2009. Arch Iran Med 2010;13:91-8.  Back to cited text no. 11
12.Jandaghi NZ, Azad TM, Naseri M, Yavarian J, Nategh R. Molecular and genetic characteristics of hemagglutinin and neuraminidase in Iranian 2009 pandemic influenza A (H1N1) viruses. Arch Virol 2010;155:717-21.  Back to cited text no. 12
13.Haghdoost AA, Gooya MM, Baneshi MR. Modelling of H1N1 flu in Iran. Arch Iran Med 2009;12:533-41.  Back to cited text no. 13
14.Moghadami M, Moattari A, Tabatabaee HR, Mirahmadizadeh A, Rezaianzadeh A, Hasanzadeh J, et al. High titers of hemagglutination inhibition antibodies against 2009 H1N1 influenza virus in Southern Iran. Iran J Immunol 2010;7:39-48.  Back to cited text no. 14
15.Khazaeipour Z, Ranjbarnovin N, Hoseini N. Influenza immunization rates, knowledge, attitudes and practices of health care workers in Iran. J Infect Dev Ctries 2010;4:636-44.  Back to cited text no. 15
16.Gouya MM, Nabavi MM, Haghdoust AA, Ghalehee S, Hemmati P, Naser Dadras M, et al. Mortality from Pandemic Influenza A (H1N1) in Iran. Iran Red Cresent Med J 2011;13:698-701.  Back to cited text no. 16
17.Mehrabi Tavana A. Influenza A (H1N1) Pandemic and Lessens Learned. Hakim Med Res J (In Persian). Hakim Fall 2010;13:177-84.  Back to cited text no. 17
18.Mehrabi Tavana A. Avian and Swine Flu Infections in Human Need More Care in National and International Levels. IRCMJ 2010;12:82-3.  Back to cited text no. 18

Correspondence Address:
Ali Mehrabi Tavana
Health Management Research Center, Baqiyatallah (a.s) University of Medical Sciences, Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.102023

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