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Year : 2017  |  Volume : 10  |  Issue : 3  |  Page : 755-756
Prenatal MRI in Zika Virus Infection

Visiting professor Hainan Medical University, China; Wiwanitkit House, Bangkhae, Bangkok, Thailand

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Date of Web Publication21-Aug-2017

How to cite this article:
Wiwanitkit V. Prenatal MRI in Zika Virus Infection. Ann Trop Med Public Health 2017;10:755-6

How to cite this URL:
Wiwanitkit V. Prenatal MRI in Zika Virus Infection. Ann Trop Med Public Health [serial online] 2017 [cited 2021 Feb 28];10:755-6. Available from:

Dear Editor,

The prenatal diagnosis of brain abnormality due to Zika virus infection is an interesting issue in tropical medicine. The recent report by Guillemette-Artur et al.[1] on “prenatal brain MRI of fetuses with Zika virus infection” is very interesting. Guillemette-Artur et al.[1] found that “severe cerebral damage was observed in our series, with indirect findings suggesting that the germinal matrix is the principal target for Zika virus..” In fact, this finding is contrast to some previous reports. In a recent report by Cavalheiro et al.[2], it is noted that “there is a definitive pathognomonic radiographic pattern of microcephaly caused by Zika virus.” In addition, as noted by Guillemette-Artur et al.[1], the similar findings to that can be seen in cytomegalovirus infection is mentioned Indeed, the similarity can be expected, as both Zika virus and cytomegalovirus (CMV) can directly attack fetal brain tissue. However, there is an interesting observation, “gross” calcifications, that is not commonly observed in cases with cytomegalovirus infection.[3] In fact, although both Zika virus and CMV attack fetal brain tissue, accounting for similarities being expected regarding brain lesions, there might be argument. Parvovirus B19 and Toxoplasmosis also attack fetal brain tissue but are responsible for very different lesions due to mechanism being different. In CMV, gross or more subtle calcifications can be observed. Saying that the germinal matrix might be the principal target for Zika virus is not at all in contradiction with other reports and this hypothesis should be confirmed by further experiments.

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Conflicts of interest

There are no conflicts of interest to declare.

   References Top

Guillemette-Artur P, Besnard M, Eyrolle-Guignot D, Jouannic JM, Garel C. Prenatal brain MRI of fetuses with Zika virus infection. Pediatr Radiol 2016;46:(7)1032-9.  Back to cited text no. 1
Cavalheiro S, Lopez A, Serra S, Da Cunha A, da Costa MD, Moron A, Lederman HM. Microcephaly and Zika virus: neonatal neuroradiological aspects. Childs Nerv Syst 2016;32:(6)1057-60.  Back to cited text no. 2
Malinger G, Lev D, Lerman-Sagie T. Imaging of fetal cytomegalovirus infection. Fetal Diagn Ther 2011;29:117-26.  Back to cited text no. 3

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.213138

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