Annals of Tropical Medicine and Public Health

LETTER TO THE EDITOR
Year
: 2012  |  Volume : 5  |  Issue : 4  |  Page : 407--408

Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development


Viroj Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok -10160
Thailand




How to cite this article:
Wiwanitkit V. Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development.Ann Trop Med Public Health 2012;5:407-408


How to cite this URL:
Wiwanitkit V. Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development. Ann Trop Med Public Health [serial online] 2012 [cited 2021 Jan 20 ];5:407-408
Available from: https://www.atmph.org/text.asp?2012/5/4/407/102096


Full Text

Sir,

The problem of pandemic E. coli E104:H4 infection has become a concern at the global level. Attempts to stop the outbreak and confine the infection in a limited area are the present aims. Basically, to fight the deadly E. coli infection, use of vaccine is the first priority. [1] Indeed, formulation of a new E. coli vaccine has been continuously performed over the years. The direct inoculation to find a vaccine model is used in some experiments, but it poses risk and can induce severe diarrhea in the experimented volunteer subject. [2] In addition, a long time has to be used in finding the proper composition for future vaccine development in a traditional way. Because of the nature of the outbreak, an interesting management concept is the production of new pandemic vaccines. This can be the tool for fighting the problem. Finding a new vaccine might have been difficult in the past; however, it becomes easier in the present day using the advent vaccinomics technology. Here, the author reports on the preliminary study on findings for B cell epitopes for E. coli E104:H4. The vaccinomics approach as previously published by the author's laboratory is used. [3],[4] Briefly, the ABCpred Prediction Server [5] is used. The selected study protein is the WbwC (GenBank: AAK64375.1), which is a product of O104-specific genes. Based on the assessment, the determined epitopes include 84 NELIFRMDTDDICLPE and 77 HGLQYCRNELIFRMDT. These epitopes can be further used for manipulation to derive the new vaccine alternative for fighting the problem. Accompanied with the present advent in vaccine recombinant technology for E. coli vaccine development, [6] the new vaccine might be successfully developed based on this basic additional immunological information.

References

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2Harro C, Chakraborty S, Feller A, Denearing B, Cage A, Ram M, et al. Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic E. coli (ETEC) Vaccines. Clin none Vaccine none Immunol 2011;18:1719-27.
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