Annals of Tropical Medicine and Public Health
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 113-115

Gastric mucosa-associated lymphoid tissue: The need for prompt histologic diagnosis

1 Department of Haematology, University of Port Harcourt Teaching Hospital, PHC, Rivers State, Nigeria
2 Department of Internal Medicine, University of Port Harcourt Teaching Hospital, PHC, Rivers State, Nigeria
3 Department of Anatomical Pathology, University of Port Harcourt Teaching Hospital, PHC, Rivers State, Nigeria

Correspondence Address:
H E Omunakwe
Department of Haematology, University of Port Harcourt Teaching Hospital (UPTH), PHC, Rivers State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.85764

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Gastric mucosa-associated lymphoid tissue has a well established pathophysiologic link with Helicobacter pylori infection. Mucosa-associated lymphoid tissue (MALT) is acquired through chronic inflammation/antigenic stimulation in organs which are normally devoid of lymphoid tissue. We report a case of a 65 years old man with a two year history of dyspeptic symptoms associated with gradual weight loss and an epigastric mass. With poor response to anti-ulcer regimens in a peripheral hospital, he was offered a gastrectomy. The histologic report of the mass showed atypical lymphoid cells infiltration of the gastric mucosa up to the muscularis propria. He was promptly commenced on a standard chemotherapeutic regimen for Non Hodgkin's lymphoma, but demised before the second course of chemotherapy. This case highlights the need for prompt endoscopy with biopsy and histologic diagnosis of specimen to shorten delays in diagnosis and improve outcome of patients with gastric mucosa-associated lymphoid tissue.

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