Annals of Tropical Medicine and Public Health
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 138-142

Emerging antithrombotic drugs: A review

1 Department of Pharmacology, LLRM Medical College, Meerut, UP, India
2 Department of Medicine, IDST, Meerut, UP, India

Correspondence Address:
P Sikka
Department of Pharmacology, LLRM Medical College, Meerut, UP
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.85773

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Thromboembolic disorders are one of the disorders for which the researchers are still in search for a safe and efficient drug. Despite the widespread use of antithrombotic drugs for the prevention and treatment of arterial and venous thrombosis, thromboembolic diseases continue to be a major cause of death and disability worldwide. This shows the researchers' inefficiency in searching efficacious and safe antithrombotic drugs. The researchers have reached to the basic mechanism of thrombus formation and by interrupting various steps of this mechanism, they can prevent as well as treat thromboembolic disorders. In continuation of Aspirin, now, the researchers are using clopedogrel, Ticlopidine and GpIIb/IIIa inhibitors (Abciximab, Tirofiban and Eptifibatide). Warfarin is an old antithrombotic drug, which is still being used but due to various side effects and drug interactions, they are bound to use newer drugs. Newer antiplatelet drugs include prasugrel, ticagrelor, cangrelor and elinogrel whereas newer thrombin inhibitors are Ximelgatran and Dabigatran. Apixaban and edoxaban are also newer entry in this category as Factor Xa inhibitors. Idrabiotaparinux is an indirect inhibitor of Xa as it accelerates the activity of antithrombin. Moreover, researches and trials for better and safe drugs are going on.

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