Annals of Tropical Medicine and Public Health
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Year : 2013  |  Volume : 6  |  Issue : 4  |  Page : 446-451

Antimicrobial resistance in Dschang, Cameroon

Department of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, West Region, Cameroon

Correspondence Address:
Fusi-Ngwa Catherine Kesah
Department of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, West Region
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Source of Support: Fusi-Ngwa and Payne designed, coordinated and sponsored this work, both authors participated in the processing of the specimens and in carrying out susceptibility testing in the laboratory, writing the manuscript and approved the final version, Conflict of Interest: None

DOI: 10.4103/1755-6783.127797

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Background: Health-care-associated and community infections remain problematic in most of Africa where the increasing incidences of diseases, wars, poverty, malnutrition, and general environmental deterioration have led to the gradual collapse of the health-care system. Detection of antimicrobial resistance (AMR) remains imperative for the surveillance purposes and optimal management of infectious diseases. This study reports the status of AMR in pathogens in Dschang. Materials and Methods: From May 2009 to March 2010, the clinical specimens collected at two hospitals were processed accorded to the standard procedures. Antibiotic testing was performed by E test, and antimycotics by disc-agar diffusion, as recommended by the Clinical and Laboratory Standards Institute on pathogens comprising Staphylococcus aureus (100 strains), Enterococcus faecalis (35), Klebsiella pneumoniae (75), Escherichia coli (50), Proteus mirabilis (30), Pseudomonas aruginosa (50), Acinetobacter species (20), and Candida albicans (150) against common antimicrobials. Results: There was no vancomycin resistance in the cocci, the minimum inhibitory concentration for 90% of these strains MIC 90 was 3 μg/ml, methicillin-resistant S. aureus (MRSA) was 43%, benzyl penicillin 89% resistance in S. aureus as opposed to 5.7% in E. faecalis. Low resistance (<10%) was recorded to cefoxitin, cefotaxime, and nalidixic acid (MIC 90 3-8 μg/ml) against the coliforms, and to ticarcillin, aztreonam, imipenem, gentamicin, and ciprofloxacin among the non-enterobacteria; tetracycline, amoxicillin, piperacillin, and chloramphenicol were generally ineffective. Resistance rates to fluconazole, clotrimazole, econazole, and miconazole were <55% against C. albicans. The pathogens tested exhibited multidrug-resistance. Conclusion: The present findings were intended to support antimicrobial stewardship endeavors and empiric therapy. The past, present, and the future investigations in drug efficacy will continue to be invaluable in health-care epidemiology.

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