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Table of Contents   
LETTER TO THE EDITOR  
Year : 2014  |  Volume : 7  |  Issue : 1  |  Page : 80
Mutation prone position within neuraminidase of H7N9: An important information for predicting drug-resistance


Department of Medical Science, Faculty of Medicine, University of Nis, Šumatova?ka, Niš, Serbia

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Date of Web Publication20-Nov-2014
 

How to cite this article:
Wiwanitkit V. Mutation prone position within neuraminidase of H7N9: An important information for predicting drug-resistance. Ann Trop Med Public Health 2014;7:80

How to cite this URL:
Wiwanitkit V. Mutation prone position within neuraminidase of H7N9: An important information for predicting drug-resistance. Ann Trop Med Public Health [serial online] 2014 [cited 2019 Dec 14];7:80. Available from: http://www.atmph.org/text.asp?2014/7/1/80/145048
Dear Sir,

The emerging H7N9 influenza is an important concern in present global public health. This infection is a new infection, and the present concern is on the drug resistance. The problem of antiviral drug-resistance in H7N9 influenza is first mentioned by Hu et al. in Lancet. [1] Focusing on the underlying mechanism of drug resistance, the mutation within neuraminidase is mentioned as a necessary pathobiological process.­ [2],[3] Here, the author uses a bioinformatics technique to assess the mutation prone position within neuraminidase of H7N9. The technique is a standard technique as previously used in the mutation prone position assessment in the previous outbreak of H5N1 bird flu. [4] The template in this study is GenBank: AGI60300.1. According to the assessment, from overall 465 amino acids, the mutation resistance position can be seen at 34-51, 136-143, 158-166, 175-196, 235-247, 285-296, 316-351, 401-406. This means there are more mutation prone positions than mutation resistant positions within the neuraminidase of H7N9. It is no doubt that the problem of drug-resistance will increase if the H7N9 influenza virus circulates for a long time.

 
   References Top

1.
Hu Y, Lu S, Song Z, Wang W, Hao P, Li J, et al. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 2013;381:2273-9.  Back to cited text no. 1
    
2.
Wu Y, Bi Y, Vavricka CJ, Sun X, Zhang Y, Gao F, et al. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Res 2013;23:1347-55.  Back to cited text no. 2
    
3.
Sleeman K, Guo Z, Barnes J, Shaw M, Stevens J, Gubareva LV. R292K substitution and drug susceptibility of influenza A(H7N9) viruses. Emerg Infect Dis 2013;19:1521-4.  Back to cited text no. 3
    
4.
Wiwanitkit V. HA cleavage site mutation in bird flu virus in Thailand: Relation to pathogenic degree and further surveillance. Am J Infect Control 2006;34:468.  Back to cited text no. 4
    

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Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.145048

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