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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 1  |  Page : 205-210

Study comparing ceftriaxone with azithromycin for the treatment of uncomplicated typhoid fever in children of India


Department of Paediatrics, Army College of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Bindu T Nair
Department of Paediatrics, Army College of Medical Sciences, Delhi Cantonment, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.205534

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Introduction: The typhoid fever is one of the most common and serious infections in a developing country like India. An increase in the occurrence of typhoid fever in Indian children has stimulated the evaluation of alternative drugs for treatment in the Out Patient Department (OPD) without hospitalisation. Objective: To study the feasibility of using oral azithromycin for treating blood culture positive uncomplicated typhoid fever instead of intravenous ceftriaxone in a resource poor setting. Materials and Methods: We performed a randomised controlled trial to compare the efficacy and safety of azithromycin (20 mg/kg/day) as a once daily oral dose with intravenous ceftriaxone for 7 days for the treatment of uncomplicated typhoid fever in children and adolescents in India. A total of 124 children aged 3-18 years who were suspected to have typhoid fever were randomized and studied. Statistical analysis used: Data analysis was performed using Epi Info version 7 (Centers for Disease Control, Atlanta, GA.) and SPSS for Windows version 7.5 (SPSS, Inc., Chicago, Il.). Results: Our study showed that clinical cure was achieved in 30 (100%) of 30 patients in the azithromycin group and in 30 (88.2%) of 34 patients in the ceftriaxone group. The mean time taken for clearance of bacteraemia was longer in the azithromycin group than in the ceftriaxone. No patient who received azithromycin had a relapse as compared to 5 patients who received ceftriaxone. No serious side effects occurred in any subject under study. Conclusion: Oral azithromycin could be a convenient and cheap alternative for the treatment of typhoid fever, especially in children in developing countries where medical resources are scarce.


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