| ORIGINAL ARTICLE |
|
| Year : 2012 | Volume
: 5
| Issue : 6 | Page : 574-580 |
|
|
Risk factors for antituberculosis drug-induced hepatotoxicity and its association with oxidative stress in North Indian population
Khushboo Ambreen1, Rolee Sharma2, Kaleshwar P Singh3, Faizan Haidar Khan1, Sudhir Kumar1
1 Department of Zoology, University of Lucknow, Lucknow, India
2 Department of Biotechnology, Integral University, India
3 Department of Microbiology, C. S. M. Medical University, India
Correspondence Address:
Sudhir Kumar
Department of Zoology, University of Lucknow, Human & Molecular genetics laboratory, Lucknow-226 007
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1755-6783.109278
|
|
|
Background: Antituberculosis drug-induced hepatotoxicity (anti-TB-DIH) is a worldwide serious medical problem among TB patients. Oxidative stress has also been proposed as one of the possible mechanisms involved in anti-TB-DIH. Aims: The main aim of this study was to evaluate the risk factors for anti-TB-DIH and further, to investigate the possible association of anti-TB-DIH with oxidative stress. Materials and Methods: This prospective cohort study was conducted in 244 TB patients receiving anti-TB treatment. Liver function (ALT, AST, Bilirubin) and oxidative stress parameters (Malondialdehyde, Glutathione, Superoxide dismutase) were estimated before and during the treatment period, along with clinical observation. Results: 14.3% patients developed Anti-TB-DIH. Patients with female gender, low body mass index, extra-pulmonary TB and positive HIV were significant risk factors for anti-TB-DIH. During the treatment period, patients with DIH showed a significant (P<0.0001) higher level of malondialdehyde, superoxide dismutase and a significant (P<0.0001) lower level of glutathione as compared to patients without DIH. Conclusion: In summary, we found that TB patients with female gender, low body mass index, extrapulmonary and positive HIV were at higher risk for anti-TB-DIH. Our finding further conclude that higher level of MDA with altered level of antioxidants in patients with DIH, may be due to oxidative stress-resulting from anti-TB drugs. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
