Annals of Tropical Medicine and Public Health
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Year : 2012  |  Volume : 5  |  Issue : 6  |  Page : 574-580

Risk factors for antituberculosis drug-induced hepatotoxicity and its association with oxidative stress in North Indian population

1 Department of Zoology, University of Lucknow, Lucknow, India
2 Department of Biotechnology, Integral University, India
3 Department of Microbiology, C. S. M. Medical University, India

Correspondence Address:
Sudhir Kumar
Department of Zoology, University of Lucknow, Human & Molecular genetics laboratory, Lucknow-226 007
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.109278

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Background: Antituberculosis drug-induced hepatotoxicity (anti-TB-DIH) is a worldwide serious medical problem among TB patients. Oxidative stress has also been proposed as one of the possible mechanisms involved in anti-TB-DIH. Aims: The main aim of this study was to evaluate the risk factors for anti-TB-DIH and further, to investigate the possible association of anti-TB-DIH with oxidative stress. Materials and Methods: This prospective cohort study was conducted in 244 TB patients receiving anti-TB treatment. Liver function (ALT, AST, Bilirubin) and oxidative stress parameters (Malondialdehyde, Glutathione, Superoxide dismutase) were estimated before and during the treatment period, along with clinical observation. Results: 14.3% patients developed Anti-TB-DIH. Patients with female gender, low body mass index, extra-pulmonary TB and positive HIV were significant risk factors for anti-TB-DIH. During the treatment period, patients with DIH showed a significant (P<0.0001) higher level of malondialdehyde, superoxide dismutase and a significant (P<0.0001) lower level of glutathione as compared to patients without DIH. Conclusion: In summary, we found that TB patients with female gender, low body mass index, extrapulmonary and positive HIV were at higher risk for anti-TB-DIH. Our finding further conclude that higher level of MDA with altered level of antioxidants in patients with DIH, may be due to oxidative stress-resulting from anti-TB drugs.

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