Annals of Tropical Medicine and Public Health
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Year : 2014  |  Volume : 7  |  Issue : 5  |  Page : 219-222

Distribution of ESBL producing Uropathogenic Escherichia coli and carriage of selected β-lactamase genes in Hospital and community isolates in west of Iran

1 Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
2 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
3 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah; Microbiology Department, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran

Correspondence Address:
Baharak Norozi
Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Shirudi Shahid Blvd, Daneshgah St, Kermanshah - 67148-69914
IR Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.154823

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Background and Objective: For many years, extended-spectrum-beta-lactamase (ESBL)-producing bacteria were problems mainly located in medical facilities. Within the last decade, however, ESBL-producing bacteria have started spreading into the community and the hospital. The aims of this study were to detect ESBL-producing uropathogenic Escherichia coli (UPEC), susceptibility to antibiotics, and β-lactamase genes. Materials and Methods: Two hundred bacterial isolates were collected from inpatients and outpatients in the west of Iran from December 2011 to February 2013. All isolates were identified by conventional bacteriological tests. Antimicrobial susceptibility and interpretation were assessed by disk diffusion. ESBL-producing E. coli isolates were tested by polymerase chain reaction (PCR) assay for blaTEM , blaSHV , blaCTX-M , blaOXA-I , and blaOXA-II genes. Results: Of 200 UPEC, 22% (n = 44) were ESBL-producing; 0% showed the least resistance to imipenem, and 97.7% showed high resistance to carbenicillin and ampicillin. The ESBLs CTX-M, SHV, TEM, OXAI, and OXAII were detected in 93.3%, 68.2%, 43.2%, 31.8%, and 22.7% of isolates respectively. Conclusion: A prevalence of ESBL-producing UPEC was observed in outpatients and inpatients; the high levels of resistance to different antibiotics show that treatment options are limited and that infection control measures remain of high importance.

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