Malaria is a common parasitic disease caused by Plasmodium spp. and transmitted by anopheles mosquito. Every year several million people are affected and killed due to this infection in the endemic regions of the world. Recently, drug resistance to the common antimalarial drugs has pressurized upon the development of an effective vaccine for the elimination of malaria along with other control measures. A number of vaccine trials are in the pipeline. Indeed, some were proven to have potential efficacy as therapeutic vaccine. We searched all the articles in heading malaria vaccine, recent advances in malaria vaccine, review on malaria vaccine, efficacy trials on malaria vaccine published in pubmed and google website and, review the current status and the unresolved challenges regarding malaria vaccine.