Rabies is a deadly neurological disease. The best prevention is the postexposure rabies vaccination.  In the present day, there are several techniques for vaccine administration. Both intradermal (ID) and intramuscular (IM) administration can be used and different numbers of injection site are applicable. There are some reports comparing the effectiveness among different techniques. The recent publication by Warrell et al. compared several techniques and can be useful information for further policymaking.  Nevertheless, the important concern in decisionmaking is the “cost” and “effectiveness.” In addition, the “safety” has to be considered. Here, the author performed an analysis on cost-safety-effectiveness analysis of different methods of rabies vaccination. Data on cost refers to the standard vaccine cost, in US dollars, from the Thai Red Cross Society, Thailand. The effectiveness and safety refer to the published data by Warrell et al.  The cost-safety-effectiveness analysis can be defined as cost per safe fraction of vaccine effectiveness which can be calculated by “cost/[(1% of adverse effects) × effectiveness].” The data of analysis is shown in [Table 1]. According to the analysis, in term of cost, effectiveness, and safety, the 2-site ID regimen is the most favorable method with the lowest cost with the highest safe effectiveness.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
Source of Support: None, Conflict of Interest: None