|How to cite this article:
Wiwanitkit V, Wiwanitkit S. T cell epitopes within envelope glycoprotein of Ebola virus: The clue for vaccine development. Ann Trop Med Public Health 2015;8:16
|How to cite this URL:
Wiwanitkit V, Wiwanitkit S. T cell epitopes within envelope glycoprotein of Ebola virus: The clue for vaccine development. Ann Trop Med Public Health [serial online] 2015 [cited 2020 Sep 22];8:16. Available from: https://www.atmph.org/text.asp?2015/8/1/16/156709
The 2014 Ebola virus epidemic in western Africa is the present concern in global public health. , This outbreak is believed to be one of the serious infectious epidemics in history. Generally, Ebola virus infection is a severe viral infection with high mortality. The disease is difficult to control due to lack of vaccination. To create a new vaccine, knowledge on the epitope within the virus molecule is required. Here, the author reports the preliminary assessment to find T cell epitopes within envelope glycoprotein of Ebola virus. The author used the standard immunomincs technique for analysis on the available standard Ebola virus envelope glycoprotein [Accession: Q05320.1, guard interval (GI): 465411] derived from the PubMed database. The details of the immunomics method used in this study are the same as the protocol used in the previously published work by Wiwanitkit.  According to the analysis, the nonapeptides starting at position 439, 251, and 502 are the parts that have the highest scores of T cell epileptopigenicity. Interestingly, the derived nonapeptide “STDFLDPAT” is not the same, as previously reported by Wu et al. (“LYDRLASTV”).  The data from this study could be the clue for further development of vaccines.
Reynard O, Volchkov V, Peyrefitte C. A first outbreak of Ebola virus in West Africa. Med Sci (Paris) 2014;30:671-3.
Gulland A. Health ministers in West Africa hold crisis talks on Ebola virus. BMJ 2014;348:g4478.
Wiwanitkit V. Finding a T-cell epitope for a melanoma vaccine by an immunomics technique. Asian Pac J Cancer Prev 2006;7:659-60.
Wu S, Yu T, Song X, Yi S, Hou L, Chen W. Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins. Virol J 2012;9:111.
Source of Support: None, Conflict of Interest: None