Annals of Tropical Medicine and Public Health
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CASE REPORT
Year : 2010  |  Volume : 3  |  Issue : 1  |  Page : 30-32

Herpes simplex encephalitis in a patient having common variable immuno-deficiency


Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India

Correspondence Address:
Sanjeev Jha
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.76183

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Common variable immunodeficiency (CVID) is one of the most prevalent and heterogeneous group of immunological disorders of unknown etiology, commonly associated with recurrent bacterial and protozoal infections. Viral infections in CVID are uncommon, as cellular immunity remains normal in it. Central nervous system involvement, related to viral infections, is an important, rare, and usually fatal complication occurring in the later phase of this disease. The herpes simplex encephalitis (HSE) in primary immunodeficiency states and related disorders have been infrequently reported. However, its occurrence in CVID per se is not known. We report a case of CVID, complicated by HSE, highlighting that in addition to bacterial infections and chronic enterovirus infectious meningoencephalitis, it may also be associated with acute viral encephalitis.


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