Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:3671
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2010  |  Volume : 3  |  Issue : 1  |  Page : 8-13

Distal symmetric polyneuropathy and toxic neuropathy in HIV patients


Department of Neurology, Faculty of Medicine, Addis Ababa University, Ethiopia

Correspondence Address:
Belachew Degefe Arasho
Department of Neurology, Faculty of Medicine, Addis Ababa University
Ethiopia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.76177

Rights and Permissions

Several neurological diseases have been associated with Human Immunodeficiency Virus (HIV) infection. These could either be a direct result of the virus (HIV associated dementia and HIV related painful distal polyneuropathy) or of opportunistic infections or neoplasm. HIV related neuropathy is one of the most common neurological complications of HIV infection. There are various forms of neuropathy in HIV patients which can be broadly classified into: (i) distal symmetric polyneuropathy (DSP), (ii) mononeuropathy multiplex (iii) acute and chronic inflammatory demyelinating polyneuropathies (iv) lumbosacral polyradiculopathy (v) diffuse infiltrative lymphocytosis syndrome (DILS) (vi) autonomic neuropathy, mononeuropathies (vii) herpes zoster radiculitis and (viii) sensory ganglioneuritis. DSP represents the most common form of neuropathy seen in patients with HIV and affects about 30% of patients. Pathologic findings of DSP occur in almost all patients with advanced immunodeficiency at autopsy. However, with HAART, the incidence of DSP appears to be decreasing compared to the pre-HAART era. Some studies show a substantial increase in the prevalence of DSP and this may be related to an increased longevity of patients and neurotoxic effects of some anti-retroviral drugs. Anti-retroviral toxic neuropathy (ATN) occurs with the di-deoxnucleoside group of drugs (DDI, stavudine, and DDC) and is thought to be the direct neurotoxic effect of the drugs. The two forms are clinically indistinguishable and present in a length dependent axonal polyneuropathy. DSP and ATN cause devastating complications and are related to poor treatment compliance. The objective of this review is to update current knowledge in the two main forms of neuropathy in HIV infection. We believe that physicians practicing in highly HIV prevalent areas (Sub-Saharan Africa and other developing countries) need to look for these complications in their HIV patients and manage them accordingly.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3963    
    Printed176    
    Emailed2    
    PDF Downloaded17    
    Comments [Add]    
    Cited by others 1    

Recommend this journal