Annals of Tropical Medicine and Public Health
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 91-95

A fatal case of Trypanosoma lewesi in Maharashtra, India

1 State Health System Resource Centre, University of Pune, Pune - 411 007, India
2 School of Health Sciences, University of Pune, Pune - 411 007, India

Correspondence Address:
P P Doke
State Health System Resource Centre, Parivartan Building, Arogya Bhavan, Alanid Road, Yerwada, Pune - 411 006
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.85759

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In the state of Maharashtra, India, in the three years 2004-05 to 2006-07, animal Trypanosoma parasites T. lewisi and T. evansi resulted in human illnesses in three different geographical regions. The first two cases have already been reported. The recent case was a man aged 57 years, residing in a small village in district Pune. Since September 2006 he had chronic intermittent fever, anemia, firm hepatosplenomegaly and edema on feet. The investigations in March 2007 revealed that it was a case of T. lewisi. The primary epidemiological investigations showed no other cases in the village. The investigations pointed to the probability of transmission through rat fleas. The case was brought under Suramin treatment in the B.J. Medical College and Sassoon General Hospital Pune. The patient expired after second dose in June 2007. His blood was sent for genetic study in the School of Health Sciences, University of Pune. The genetic study for mutation in the APOL 1 gene revealed that the four DNA fragments from the patient did not have any mutation in the amplified exonic fragments.

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