Annals of Tropical Medicine and Public Health
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 96-98

Prevalence of extended spectrum β-lactamase-producing clinical isolates of Klebsiella pneumoniae in intensive care unit patients of a tertiary care hospital

Department of Microbiology, J N Medical College, Belgaum - 590 010, Karnataka, India

Correspondence Address:
Sheetal Harakuni
Department of Microbiology, J N Medical College, Belgaum - 590 010, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.85760

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Aim: To identify the extended-spectrum β-lactamase producing Klebsiella pneumoniae (ESBL-KP) isolated from intensive care unit (ICU) patients of a tertiary care hospital. Materials and Methods: Seventy Klebsiella pneumoniae clinical isolates from ICU patients were screened for ESBL production. All were confirmed for ESBL production by potentiated disc diffusion test. Minimum inhibitory concentrationby agar dilution technique was performed. Sensitivity to other group of drugs was determined by Kirby-Bauer method against ciprofloxacin, amikacin, co-trimoxazole. Results: In all, 74% of the isolates were ESBL-KP; 57% were from blood samples. Coresistance to other group of drugs ranged from 63 to 83%. Conclusion: There is a high prevalence of ESBL-KP. The prompt reporting of ESBL producing bacteria is necessary to prevent their dissemination. This alarms for strict infection control measures to be practised in hospital settings.

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