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ORIGINAL ARTICLE
Year : 2012  |  Volume : 5  |  Issue : 3  |  Page : 181-184

Etiology and sensitivity of uropathogens in outpatients and inpatients with urinary tract infection: Implications on empiric therapy


Department of Microbiology, Yenepoya Medical College, Nithyanandanagar, Deralakatte, Mangalore, India

Correspondence Address:
Vidya Pai
Department of Microbiology, Yenepoya Medical College, Yenepoya University, Nithyanandanagar, Deralakatte, Mangalore-575018
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.98610

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Background and Objectives: Urinary Tract Infections (UTI) are the second most common infections after the respiratory tract infections and constitute a great proportion of prescription of antibiotics. The present study was designed to determine the etiology of uropathogens and their susceptibility pattern in outpatients and inpatients of our hospital so as to arrive at an empirical treatment for patients with UTI. Materials and Methods : A total of 924 urine samples were obtained from inpatients and outpatients with a clinical diagnosis of UTI. The samples were cultured and antibiotic susceptibility of isolates determined by disc diffusion method. Results: Of 924 urine samples processed (828 from inpatients and 96 from outpatients), 262 (28.35%) yielded bacterial isolates. About 216 (26.08%) samples from inpatients and 46 (47.9%) from outpatients showed significant bacteriuria. Escherichia coli predominated in both groups, followed by Klebsiella spp., Pseudomonas spp., Acinetobacter spp., and Enterobacter spp., which were isolated from only the inpatient samples. Sensitivity to nitrofurantoin varied from 73% to 94% and fluoroquinolone resistance was documented as 11%-80%. Resistance to amikacin, ceftazidime, and ceftriaxone was less than 25%. Imipenem resistance was found in <5% of the bacterial isolates. Conclusion: E. coli and Klebsiella spp. are the major uropathogens. Resistant strains are prevalent in the community, as evident by the fact that there is not much difference in resistance patterns of isolates from inpatients and outpatients. Taking into account the resistant pattern, nitrofurantoin represents the option of first choice for empirical therapy of uncomplicated UTI.


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