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Table of Contents   
LETTER TO THE EDITOR  
Year : 2012  |  Volume : 5  |  Issue : 4  |  Page : 407-408
Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development


Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

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Date of Web Publication8-Oct-2012
 

How to cite this article:
Wiwanitkit V. Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development. Ann Trop Med Public Health 2012;5:407-8

How to cite this URL:
Wiwanitkit V. Finding for B cell epitopes for E. coli E104:H4, a first step for vaccine development. Ann Trop Med Public Health [serial online] 2012 [cited 2018 May 21];5:407-8. Available from: http://www.atmph.org/text.asp?2012/5/4/407/102096
Sir,

The problem of pandemic E. coli E104:H4 infection has become a concern at the global level. Attempts to stop the outbreak and confine the infection in a limited area are the present aims. Basically, to fight the deadly E. coli infection, use of vaccine is the first priority. [1] Indeed, formulation of a new E. coli vaccine has been continuously performed over the years. The direct inoculation to find a vaccine model is used in some experiments, but it poses risk and can induce severe diarrhea in the experimented volunteer subject. [2] In addition, a long time has to be used in finding the proper composition for future vaccine development in a traditional way. Because of the nature of the outbreak, an interesting management concept is the production of new pandemic vaccines. This can be the tool for fighting the problem. Finding a new vaccine might have been difficult in the past; however, it becomes easier in the present day using the advent vaccinomics technology. Here, the author reports on the preliminary study on findings for B cell epitopes for E. coli E104:H4. The vaccinomics approach as previously published by the author's laboratory is used. [3],[4] Briefly, the ABCpred Prediction Server [5] is used. The selected study protein is the WbwC (GenBank: AAK64375.1), which is a product of O104-specific genes. Based on the assessment, the determined epitopes include 84 NELIFRMDTDDICLPE and 77 HGLQYCRNELIFRMDT. These epitopes can be further used for manipulation to derive the new vaccine alternative for fighting the problem. Accompanied with the present advent in vaccine recombinant technology for E. coli vaccine development, [6] the new vaccine might be successfully developed based on this basic additional immunological information.

 
   References Top

1.Panda A, Tatarov I, Melton-Celsa AR, Kolappaswamy K, Kriel EH, Petkov D, et al. Escherichia coli O157: H7 infection in Dutch beted and New Zealand white rabbits. Comp Med 2010;60:31-7.  Back to cited text no. 1
[PUBMED]    
2.Harro C, Chakraborty S, Feller A, Denearing B, Cage A, Ram M, et al. Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic E. coli (ETEC) Vaccines. Clin none Vaccine none Immunol 2011;18:1719-27.  Back to cited text no. 2
[PUBMED]    
3.Wiwanitkit V. Predicted B-cell epitopes on 18 kDa antigen of Haemophilus ducreyi. Indian J Dermatol Venereol Leprol 2008;74:676- 7.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.Wiwanitkit V. Predicted B-cell epitopes of HER-2 oncoprotein by a bioinformatics method: A clue for breast cancer vaccine development. Asian Pac J Cancer Prev 2007;8:137-8.  Back to cited text no. 4
[PUBMED]    
5.Saha S, Raghava GP. Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 2006;65:40-8.  Back to cited text no. 5
[PUBMED]    
6.Svennerholm AM. From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development. Indian J Med Res 2011;133:188-96.  Back to cited text no. 6
[PUBMED]  Medknow Journal  

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Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok -10160
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.102096

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