Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:1575
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 2013  |  Volume : 6  |  Issue : 1  |  Page : 59-64

Human cytomegalovirus infection in Nigerians living with human immunodeficiency virus

1 Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria
2 Stony Brook University School of Medicine (SUNY), New York, USA
3 Clinical Sciences Division, Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria
4 Al-Nuri Specialist Hospital, Surulere, Lagos State, Nigeria

Correspondence Address:
Olaoluwa P Akinwale
Molecular Parasitology Research Laboratory, Public Health Division, Nigerian Institute of Medical Research, P.M.B. 2013, Yaba, Lagos State
Login to access the Email id

Source of Support: Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria, Conflict of Interest: None

DOI: 10.4103/1755-6783.115205

Rights and Permissions

Context : Human immunodeficiency virus (HIV) patients are at higher risk for Human cytomegalovirus (HCMV) infection. Aim: To identify HCMV and HIV co-infection among Nigerian patients for prompt therapeutic interventions. Materials and Methods: The study drew samples from the antiretroviral clinic of Nigerian Institute of Medical Research and patients' informed consent was taken at enrollment. Variables collected included socio-demographic characteristics such as sex, occupation, marital status, educational status, income, and religion, while health-related variables were CD4 counts and HIV viral load. Genomic DNA from whole blood samples of 236 patients, 164 (69.5%) females and 72 (30.5%) males, was subjected to polymerase chain reaction (PCR) amplification of 2 genes within conserved immediate early (IE) and late (LA) transcribed regions of HCMV genome. Statistical Analysis: Statistical Package for Social Sciences was used to determine frequencies of HMCV infection, while Chi square was used to examine associations between patient's characteristics and HMCV infection. Results: A total of 35 (14.8%) patients; 25 (10.6%) females and 10 (4.2%) males were positive for HCMV infection. Although there was variation in prevalence of HCMV in different marital status, it was statistically insignificant (P = 0.734; P > 0.05). Results also showed that 22 (62.9%) of HCMV positive patients had HIV viral load greater than 10,000, prevalence of HCMV decreased as CD4 counts increased, while 12 (34.3%) of HCMV positive patients had CD4 counts between 1 and 200. Conclusions: This study is the first molecular survey of HCMV/HIV co-infection in Nigeria and has provided valuable information for prompt therapeutic intervention to reduce morbidity among HIV patients.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded12    
    Comments [Add]    

Recommend this journal