Annals of Tropical Medicine and Public Health
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Year : 2013  |  Volume : 6  |  Issue : 3  |  Page : 343-344

Isolated immunoglobulin A (IgA) deficiency presenting with cytomegalo virus pneumonia

1 Department of Pediatrics, All India Institute of Medical Sciences, Bhopal, India
2 Department of Pediatrics, PGIMER, Dr. RML Hospital, New Delhi, India

Correspondence Address:
Jhuma Sankar
Department of Pediatrics, PGIMER, Dr. RML Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.121003

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A 5-month-old infant with an uneventful perinatal period was presented with lower respiratory tract symptoms and abnormal X-ray findings of 1-month duration. At admission, the baby was in respiratory distress requiring oxygen therapy and supportive care. Despite optimal supportive care and antibiotic therapy, he continued to be symptomatic necessitating further investigations for nonresolving pneumonia. His bronchoalveolar lavage and urine were positive for cytomegalovirus (CMV) and workup for immunodeficiency showed undetectable immunoglobulin A(IgA) levels. Rest of the workup was inconclusive. We investigated the mother for a carrier status, but the workup was negative for CMV and/or other intrauterine infections. In view of severe CMV-associated lung disease, the baby was started on ganciclovir therapy for 6 weeks on which he recovered completely. Although the associated isolated IgA deficiency may be an incidental finding in this case, it is indeed intriguing and requires further research.

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