Annals of Tropical Medicine and Public Health
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Year : 2013  |  Volume : 6  |  Issue : 3  |  Page : 369-377

A study of patients with type II respiratory failure put on non-invasive positive pressure ventilation

Department of Medicine, V. S. General Hospital, Ahmedabad, India

Correspondence Address:
Vishal Vanani
E/6, Doctor's Quarters, V. S. General Hospital, Ellisbridge, Ahmadabad - 380 006, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.121015

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Non-invasive ventilation as an alternative to the endotracheal intubation is associated with less infectious complications and injury to the airways. In a study cohort that included 50 patients with type II respiratory failure with the commonest diagnosis of chronic obstructive pulmonary disease (COPD) exacerbation with or without associated co-morbidities, mechanical ventilation with non-invasive positive pressure ventilation (NIPPV) was applied and the response was observed in terms of change in various clinical and laboratory parameters after 1 hour, at the time of weaning, and 6 hours after weaning. There was significant improvement with NIPPV in form of increase in pH and PaO 2 and decrease in PaCO2 and HCO3 after 1 hour of NIPPV application, which also persisted after successful weaning. The patients who failed NIPPV had significantly high respiratory rate, low pH value, and high PaCO 2 on admission.

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