Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:307
currentissue backissue special isse search   Print this page  Email this page Small font sizeDefault font sizeIncrease font size
 


 
Table of Contents   
LETTER TO THE EDITOR  
Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 74
QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis


1 Medical Science, Medical Center, Shantou, China
2 Department of Tropical Medicine, Hainan Medical University, China

Click here for correspondence address and email

Date of Web Publication25-May-2015
 

How to cite this article:
Tin SS, Wiwanitkit V. QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis. Ann Trop Med Public Health 2015;8:74

How to cite this URL:
Tin SS, Wiwanitkit V. QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis. Ann Trop Med Public Health [serial online] 2015 [cited 2019 Jun 17];8:74. Available from: http://www.atmph.org/text.asp?2015/8/3/74/157642
Dear Sir,

The usefulness of QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis is interesting. The use of these two tests in the case of patients with some specific concomitant medical disorders should be discussed. Of several conditions, psoriasis is an interesting underlying problem to be considered. Although both QFT-GIT and TST for the screening of latent tuberculosis are widely assessed for their diagnostic properties, psoriasis is a complex immunologic disorder; therefore, it is not possible to project the results of other studies to a study population of psoriasis patients. Duman et al. concluded that "the cut-off point for TST positivity in psoriasis and PA patients should be re-evaluated, or other tests, such as the QFT-GIT, should be used." [1] The conclusions of Duman et al. are pertinent for only those patients with psoriasis. In fact, as an interferon-gamma release assay, QFT-GIT is approved for its efficacy in the diagnosis of latent tuberculosis. [2] However, it should be noted that many reports did not show QFT-GIT as having better efficacy than the standard TST. [3],[4] Finally, the cost-effectiveness of QFT-GIT should also be discussed. It seems that the higher cost of QFT-GIT might be a big obstacle for using this test in resource-limited settings where tuberculosis is usually endemic. [5] Nevertheless, there is not enough literature regarding the costs in case of psoriasis patients. In some cases, antitumor necrosis factor (anti-TNF) agents are used and in case of false negative TST, the cost will increase if the patient dies or if there is a need for tuberculosis treatment.

 
   References Top

1.
Duman N, Ersoy-Evans S, Karadağ O, Aşçıoğlu S, Sener B, Kiraz S, et al. Screening for latent tuberculosis infection in psoriasis and psoriatic arthritis patients in a tuberculosis-endemic country: A comparison of the QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test. Int J Dermatol 2014;53:1286-92.  Back to cited text no. 1
    
2.
De Keyser E, De Keyser F, De Baets F. Tuberculin skin test versus interferon-gamma release assays for the diagnosis of tuberculosis infection. Acta Clin Belg 2014;69:358-66.  Back to cited text no. 2
[PUBMED]    
3.
Verhagen LM, Maes M, Villalba JA, d'Alessandro A, Rodriguez LP, España MF, et al. Agreement between QuantiFERON ® -TB Gold In-Tube and the tuberculin skin test and predictors of positive test results in Warao Amerindian pediatric tuberculosis contacts. BMC Infect Dis 2014;14:383.  Back to cited text no. 3
    
4.
Rutherford ME, Nataprawira M, Yulita I, Apriani L, Maharani W, van Crevel R, et al. QuantiFERON ® -TB Gold In-Tube assay vs. tuberculin skin test in Indonesian children living with a tuberculosis case. Int J Tuberc Lung Dis 2012;16:496-502.   Back to cited text no. 4
    
5.
Wiwanitkit V. Field QuantiFERON-TB gold test. Am J Infect Control 2011;39:447.  Back to cited text no. 5
[PUBMED]    

Top
Correspondence Address:
Prof. Sim Sai Tin
Medical Center, Shantou
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.157642

Rights and Permissions




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *


    References

 Article Access Statistics
    Viewed775    
    Printed19    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal