Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:2714
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2015  |  Volume : 8  |  Issue : 6  |  Page : 262-266

Acute viral encephalitis clinical features and outcome: Experience from a tertiary center of North India


1 Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
3 Deptartment of Endocrinology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India

Correspondence Address:
Manish Gutch
D-15, Lala Lajpat Rai Memorial Medical College, Meerut - 250 004, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.162640

Rights and Permissions

Background: Acute viral encephalitis (AVE) is an unconscious state that either accompanies or follows a short febrile viral illness and is characterized by a diffuse and nonspecific brain insult manifested by the combination of coma, seizures, and decerebration and frequently results in delayed neurological deficit. Aim and Objective: To evaluate the clinical features and the outcomes of patients presenting with AVE. Materials and Methods: The patients presenting with AVE with serologically confirmed viral parameters were consecutively recruited from the department of medicine/neurology from a tertiary care center of Lucknow, Uttar Pradesh, India. These patients were then subjected to detailed clinical examination, laboratory examination, and radiological assessment. The modified Rankin Scale (mRS) was calculated at the time of discharge and after 1 month of follow-up. Results: One hundred and eight patients were diagnosed with AVE over a period of 2 years. The mean age of the patients of AVE was 28.97 ± 16.7 years. The most common complaints were fever (100%), headache (94.4%), and altered mental state (92.5%). Out of the 108 patients, Japanese encephalitis (JE) was the most common etiology followed by herpes simplex virus (HSV) encephalitis. Of the total number of patients, 27 died, 9 were diagnosed with JE, 4 with hematopoietic stem cell (HSC) encephalitis, 5 with miscellaneous group, and 11 with the nonspecific group of viral encephalitis (NSAVE). The mRS at discharge was <3 in 44 patients and >3 in 35 patients with AVE. After 1 month, mRS was <3 in 57 patients and >3 in 22 patients with AVE. Conclusion: In this study, JE meningitis was the leading cause of AVE followed by NSAVE and HSV encephalitis. The outcome in cases with AVE can be fatal or more disabling than other etiologies and prompt diagnosis and supportive care remain the backbone of treatment.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3279    
    Printed33    
    Emailed0    
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal