Annals of Tropical Medicine and Public Health
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CASE REPORT
Year : 2015  |  Volume : 8  |  Issue : 6  |  Page : 296-299

Spectrum of histopathological findings in patients with acute kidney injury following H1N1 influenza infection: A study of three cases


1 Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India
2 Department of Nephrology and Clinical Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India

Correspondence Address:
Aruna V Vanikar
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney diseases And Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad - 380 016, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.162614

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Acute kidney injury (AKI) and failure can be found in association with swine-associated influenza A (H1N1) virus contributing to increased morbidity and mortality. We present three cases of H1N1 infection with AKI, the first in the background of renal amyloidosis, the second in a kidney transplant recipient, and the third in a patient who presented with renal failure following upper respiratory tract infection. Renal biopsy in all of them revealed mesangial prominence with tubulointerstitial nephritis. All of them recovered following conservative management. H1N1 infection is known to be associated with dismal prognosis and kidney involvement is mainly in the tubulointerstitial compartment. Contrary to the reported literature mentioning poor prognosis, all three patients in our study recovered fully.


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