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Table of Contents   
LETTER TO THE EDITOR  
Year : 2016  |  Volume : 9  |  Issue : 3  |  Page : 208-209
Change of platelet count during hospitalization in patients with Ebola virus disease


1 Wiwanitkit House, Bangkok, Thailand
2 Hainan Medical University, Haikou, Hainan, China; University of Niš, Niš, Serbia; Joseph Ayo Babalola University, Nigeria

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Date of Web Publication3-May-2016
 

How to cite this article:
Wiwanitkit S, Wiwanitkit V. Change of platelet count during hospitalization in patients with Ebola virus disease. Ann Trop Med Public Health 2016;9:208-9

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Change of platelet count during hospitalization in patients with Ebola virus disease. Ann Trop Med Public Health [serial online] 2016 [cited 2019 Dec 5];9:208-9. Available from: http://www.atmph.org/text.asp?2016/9/3/208/179119
Dear Sir,

Ebola virus disease is the new emerging viral infection. It is a disease with severe clinical manifestation and critical care is usually required. The platelet change is a common finding in patients with the Ebola virus disease. However, the change of platelet count during the course of illness has not been well-mentioned. Here, the authors analyzed the available data on platelet count among the hospitalized patients with Ebola virus disease in reported cases. From seven reports on 20 hospitalized patients with Ebola virus disease, all had thrombocytopenia on the hospitalization day.[1],[2],[3],[4],[5],[6],[7] This can confirm the nature of hemorrhagic disease. Further studying on two reports on three patients with available data on platelet change during hospitalization, the lowest peak of decreased platelet level can be detected between day 14 and day 17 of illness (average 16 ± 1.7). After that period, the platelet count slightly increases. Focusing on the lowest platelet count, it was between 10 and 46 × 103/mm 3 (average 22.0 ± 20.8 × 103/mm 3) and the magnitude of decreased platelet count from the first observed platelet count at hospitalization (between 20 and 103 × 103/mm 3; average 51.0 ± 45.3 × 103/mm 3) was between 10 and 57 × 103/mm 3 (average 24.0 ± 29.7 × 103/mm 3). It can be seen that platelet count usually decreases between 2 and 3 weeks of illness and the decrease is about 50% of the level detected on first hospitalization. Nevertheless, the authors' conclusions from the available data might be partial, biased by the current reported cases as controlled platelet count measurements were not performed. This letter can support a current literature on the disease. Although, at present, the disease might be no longer considered a hemorrhagic fever due to the paucity of hemorrhagic manifestations and the lack of clear correlation to platelet count and bleeding, the present report still present the importance of platelet follow-up in patient care.[8]

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Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 2014;371:1418-25.  Back to cited text no. 1
    
2.
Fletcher TE, Brooks TJ, Beeching NJ. Ebola and other viral haemorrhagic fevers. BMJ 2014;349:g5079.  Back to cited text no. 2
    
3.
Gostin LO, Lucey D, Phelan A. The Ebola epidemic: A global health emergency. JAMA 2014;312:1095-6.  Back to cited text no. 3
    
4.
Green A. WHO and partners launch Ebola response plan. Lancet 2014;384:481.  Back to cited text no. 4
    
5.
Kraft CS, Hewlett AL, Koepsell S, Winkler AM, Kratochvil CJ, Larson L, et al.; Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit. The use of TKM-100802 and convalescent plasma in 2 patients with Ebola virus disease in the United States. Clin Infect Dis 2015;61:496-502.  Back to cited text no. 5
    
6.
Lyon GM, Mehta AK, Varkey JB, Brantly K, Plyler L, McElroy AK, et al.; Emory Serious Communicable Diseases Unit. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 2014;371:2402-9.  Back to cited text no. 6
    
7.
Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, et al. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 2014;371:2394-401.   Back to cited text no. 7
    
8.
WHO Ebola Response Team. Ebola virus disease in West Africa – The first 9 months of the epidemic and forward projections. N Engl J Med 2014;371:1481-95.  Back to cited text no. 8
    

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Correspondence Address:
Somsri Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.179119

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