Annals of Tropical Medicine and Public Health
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Year : 2017  |  Volume : 10  |  Issue : 1  |  Page : 199-204

Assessment of seroprevalence of hepatitis C virus-specific antibodies among patients attending hospital of semi-urban North India using rapid qualitative in vitro diagnostic test

1 Department of Microbiology, Hind Institute of Medical Sciences, Sitapur, India
2 Department of Microbiology, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Razia Khatoon
Department of Microbiology, Hind Institute of Medical Sciences, Sitapur, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.205586

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Background and Objectives: Hepatitis C virus (HCV) is an important cause of blood-borne viral hepatitis throughout the world. Acute infection is usually silent and detected on the basis of raised liver enzymes and antihepatitis C antibody in patient's serum. Chronic infection may lead to hepatocellular carcinoma and liver cirrhosis. The present study was done to evaluate the seroprevalence of anti-HCV antibodies among patients using rapid qualitative in vitro diagnostic test. Materials and Methods: A total of 1,076 patients' blood samples were taken for testing antiHCV antibodies using rapid in vitro diagnostic test kit. Results: Out of 1,076 patients whose sera were tested, 18 were found to be reactive to antihepatitic C virus antibody giving the prevalence to be 1.7%. Out of 18 reactive patients majority belonged to inpatient department (88.9%) as compared with outpatient department (11.1%). Majority of the reactive patients belonged to age group 26-35 years (72.2%), were from rural areas (83.3%), were illiterate (77.7%), were skilled workers (66.7%), and belonged to socioeconomic class 3 (55.5%). Among the reactive patients, the most frequent risk factor for antihepatitis C antibody was found to be history of injecting drug abuse and tattooing and body piercing (22.2% each). Conclusion: Hepatitis C infection is usually a silent disease and therefore stringent screening for antihepatitis C antibody should be done in all patients using rapid in vitro diagnostic kits in order to timely diagnose the infection and initiation of treatment, thereby, preventing its adverse sequelae and also its spread to other patients.

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