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Table of Contents   
LETTER TO THE EDITOR  
Year : 2017  |  Volume : 10  |  Issue : 4  |  Page : 1078
Prediction of cytomegalovirus specific immunoglobulin structure


1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Hainan Medical University, China

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Date of Web Publication5-Oct-2017
 

How to cite this article:
Joob B, Wiwanitkit V. Prediction of cytomegalovirus specific immunoglobulin structure. Ann Trop Med Public Health 2017;10:1078

How to cite this URL:
Joob B, Wiwanitkit V. Prediction of cytomegalovirus specific immunoglobulin structure. Ann Trop Med Public Health [serial online] 2017 [cited 2019 Nov 19];10:1078. Available from: http://www.atmph.org/text.asp?2017/10/4/1078/196687


Dear Editor,

Cytomegalovirus is an important infection and is the present public health problem in many countries. In some cases, the severe infection can be seen and this becomes a hard-to-manage disease. The problem is common in the children and impaired immune hosts.[1] The use of immunotherapy for the management of cytomegalovirus infection is interesting but the big problem is that a specific immunoglobulin to treat cytomegalovirus is still not available.[2] Bhat et al. noted that the presently available general “intravenousimmunoglobulin, although used commonly in CMV pneumonia, is not very clear”.[3] Here, the authors use the bioinformatics analysis to construct the model of cytomegalovirus specific immunoglobulin structure, using the standard tool namely PIGS (prediction of immunoglobulin structure). This tool is based on the concept of canonical structures of antibody loops as well as on the concept of the light and heavy chains being packed together.[4] The template for construction is the light and heavy chain antibody of human beings (Accession: AAB35862.1 and Accession: AAS01770.1), and the approach of graft all loops-backbone only is used. Based on the construction, a new immunoglobunlin with 963 atoms can be derived [Figure 1].
Figure 1: Predicted cytomegalovirus specific immunoglobulin structure

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Plotkin S. The history of vaccination against cytomegalovirus. Med Microbiol Immunol 2015;204:247-54.  Back to cited text no. 1
[PUBMED]    
2.
Boeckh M, Murphy WJ, Peggs KS. Recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies. Biol Blood Marrow Transplant 2015;21:24-9.  Back to cited text no. 2
[PUBMED]    
3.
Bhat V, Joshi A, Sarode R, Chavan P. Cytomegalovirus infection in the bone marrow transplant patient. World J Transplant 2015;5:287-91.  Back to cited text no. 3
[PUBMED]    
4.
Marcatili P, Olimpieri PP, Chailyan A, Tramontano A. Antibody modeling using the prediction of immunoglobulin structure (PIGS) web server. Nat Protoc 2014;9:2771-83.  Back to cited text no. 4
[PUBMED]    

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Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1755-6783.196687

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