Annals of Tropical Medicine and Public Health
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Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1500-1504

Tanacetum parthenium relieves chronic constriction injury-induced neuropathic pain in male rats

1 Department of Physiology, Faculty of Medicine; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
2 Student Research Committee, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3 Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

Correspondence Address:
Ali Ghanbari
Research Center of Physiology, Semnan University of Medical Sciences, Semnan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ATMPH.ATMPH_418_17

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Background: Neuropathic pain is a chronic developing pain due to injury or disease-involving somatosensory systems such as vascular disorders, autoimmune diseases, inflammation, and traumatic injuries. Herbal medicines were utilized for the treatment of various diseases too late. The aim of this study was to evaluate the effect of Tanacetum parthenium(TP) extract on chronic constriction injury(CCI)-induced neuropathic pain. Materials and Methods: In the present study, 48 adult male Wistar rats weighing 200–250g were used. After anesthetizing the animals, CCI was performed on the left sciatic nerve for inducing neuropathic pain. TP extracts were intragastrically administered daily for 2weeks by a gavage tube. Mechanical allodynia and thermal hyperalgesia were assessed using Von Frey hairs and plantar test device, respectively. The data were analyzed using the one-way analysis of variance and Tukey's post hoc test. Results: CCI led to mechanical allodynia and thermal hyperalgesia. TP extract with higher doses used in this study significantly increased(P<0.001) paw withdrawal threshold in response to mechanical stimulation. Further, it increased(P<0.01) paw withdrawal latency in response to thermal stimulation. Conclusion: Chronic orally used TP extract alleviates CCI-induced neuropathic pain in male rats.

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