Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:1362
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1518-1523

Evaluation of oxidative stress marker in patients with human papillomavirus infection


1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran,, Iran
2 Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran
3 Department of Biochemistry, Faculty Member of Islamic Azad University, Science and Research Branch of Tehran, Tehran, Iran
4 Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
5 Department of Biostatistics and Epidemiology, Patient Safety Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Correspondence Address:
Mohamad Hasan Khadem Ansari
Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_464_17

Rights and Permissions

Introduction and Objective: Human papillomavirus(HPV) unenveloped viruses with double-stranded circular DNA cause infection in skin epithelial cells and mucosal surfaces. HPV infection has been detected in more than 70% of cervical cancers throughout the world. Among the effective factors in the progression of HPV infection are oxidative stress and oxidative markers, and the oxidative stress during viral infection can be due to the host immune responses to viral proteins or as a result of viral genes expression. This study aims to compare the mean serum level of oxidative malondialdehyde(MDA) marker and the mean of 8-Hydroxyguanosine(8- OhdG) in two groups of healthy people and patients with HPV infection. Methods: This is a descriptive, cross-sectional study in which 30patients with HPV infection and 35 healthy people(as the control group) were selected using convenience sampling method. After obtaining written consent from the subjects, the researchers took fasting blood samples and morning urine samples from them. Serum MDA was measured using the spectrophotometric method, and 8-OHdG was measured using the competitive enzyme-linked immunosorbent assay method. Finally, the data were analyzed using SPSS version 17. Results: The results of this study showed that the mean and standard deviation of serum MDA concentration have increased significantly in patients with HPVs infection(4.56±1.64 nM) than in the control group(1.64±0.37 nM). The mean and standard deviation of urinary concentration(8-OHDG) in patients with HPV infection was 14.61±1.39ng/ml while it was 9.66±1.74ng/ml in the control group. It was significantly higher in people who had high-risk HPV infection than in the group with low-risk HPV(P<0.001). Conclusion: Based on the results of this study, oxidative reactions and biological damage caused by these reactions as a result of the increased oxidative stress in the body can be suggested as a mechanism involved in the progression of the cervical papillomavirus infection and the cancer caused by it.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1643    
    Printed70    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    

Recommend this journal