Annals of Tropical Medicine and Public Health
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Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1547-1551

Prophylactic efficacy of levetiracetam on migraine headaches in children aged 4–14-year-old

1 Department of Pediatrics,Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran, India
2 Department of Biostatistics and Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Bahare Yavari
Medical School, Kermanshah University of Medical Sciences, Kermanshah
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ATMPH.ATMPH_499_17

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Background: Migraine is the most common type of episodic headache. Migraine can affect the pediatric patients' life through absence from school and restricting inside-home and social activities. Objective: This study was done with the objective of investigating the prophylactic effect of levetiracetam on pediatric migraine headaches. Materials and Methods: In this before-after clinical trial, 30 children aged 4–14years with migraine headache were included and followed for 6months. The required data were gathered through observation, examination, paraclinical studies, and interview. The data were entered into a checklist. Furthermore, the Pediatric Migraine Disability Assessment(PedMIDAS) questionnaire was used to assess disability. Levetiracetam tablet was administered for 6months. The frequency and duration of migraine headaches as well as migraine-related symptoms and possible side effects were documented. The data were then analyzed by theSPSSsoftware(ver.20.0, IBM Company). Results: The frequency of headaches, their severity, and duration decreased significantly at the end of the study(P<0.001). After 6months of treatment, migraine attacks were recovered completely in six patients(20%). Only three patients(10%) showed side effects such as nagging and negotiating, poor sleep, and lack of appetite which neither resulted in cessation of the medication. Furthermore, the PedMIDAS score decreased significantly at the end of the study(P<0.001). Conclusion: Levetiracetam had acceptable efficacy and tolerability to be used for prophylaxis of migraine headache in children and can be a good substitute in such patients.

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