Annals of Tropical Medicine and Public Health
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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1575-1578

Accuracy of ultrasonography compared to laboratory in fetal screening, which one is more reliable?


1 Women's Health and Disease Research Center, Jahrom University of Medical Sciences, Jahrom, Iran
2 Department of Obstetrics and Gynecology, Jahrom University of Medical Sciences, Jahrom, Iran
3 Critical Care and Pain Management Research Center, Jahrom University of Medical Sciences, Jahrom, Iran

Correspondence Address:
Davari Nazanin
Department of Obstetrics and Gynecology, Jahrom University of Medical Sciences, Motahari St., Jahrom
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_521_17

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Background: The aim of this study is to compare the efficacy of nuchal translucency(NT) measurement with laboratory screening tests in prenatal diagnosis of Down syndrome(DS) and neonatal outcomes. Materials and Methods: In this cross-sectional-descriptive study, data were collected from 260 pregnancy files. Ages of pregnant women were 20–34year old who referred for prenatal care. NT was measured by ultrasound at 11–13+6 and quad marker tests at 15–18 gestational week. Data analysis was performed bySPSS21 (IBM, USA) that was considered significant with P<0.05. Result: Two-hundred and twenty-one pregnant women with average age of 26.6±4.44years were screened. Frequency of negative screening tests for DS was 188 pregnant women(88.7%) and 24(11.3%) of them positive. Amniocentesis was performed for those who had positive screening test, but their NT measurement was<3.5mm. All reports of amniocentesis were negative which was consistent with fetal NT ultrasonography reports, and all neonatal outcomes were normal after delivery follow-up. Conclusion: NT measurement and quad marker test cannot accurately predict the fetal health in the future; however, NT is more reliable than laboratory screening tests because it is more consistent with the results of amniocentesis. NT is also a safer and cheaper method than amniocentesis. Pregnant women tolerate an unfavorable psychological stress and high cost during amniocentesis. The suggested option is to assess the cell-free fetal DNA in pregnant blood instead of amniocentesis.


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