Annals of Tropical Medicine and Public Health
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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1656-1660

Analysis of the association between IL-23R rs11209026 polymorphism in rheumatoid arthritis and systemic lupus erythematosus in an Iranian population


1 Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 Razi Herbal Medicines Research Center and School of Allied Medical Sciences, Department of Hematology and Blood Transfusion, Lorestan University of Medical Sciences, Khorramabad, Iran

Correspondence Address:
Ali Asghar Kiani
Department of Hematology and Blood Transfusion, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_571_17

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Introduction: Rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) are two autoimmune inflammatory diseases with possible genetic links. In this study, the polymorphism R381Q IL-23R in patients with RA, SLE, and healthy controls and its relation to genotype was investigated. Materials and Methods: In this case-control study of 100patients with SLE, 100patients with RA and 112 healthy individuals who were referred to the rheumatology ward of some hospitals in Khorramabad(Lorestan province, west of Iran) were selected. Genomic DNA was extracted from peripheral blood and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism method. Fisher's exact test was used to compare data from genotypes and alleles between all groups. Results: It was found that polymorphism A>G rs11209026 of IL-23R gene in the control group and patients with RA had significant difference(P=0.046). However in the control group and SLE patients, there was no significant difference(P=0.51). Conclusion: The results indicate that single nucleotide polymorphism rs11209026 G>A of the IL-23R gene is possibly associated with RA. IL-23 is an important inflammatory cytokine and essential for the differentiation of Th17cells. Hence studies related to the role of Th17cells in the pathogenesis of RA would help provide more insights into its regulatory mechanisms.


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