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ORIGINAL ARTICLE
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1770-1773

Prognostic factors of sepsis rapid progression in patients admitted to Intensive Care Unit


1 Anti-microbial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
4 Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
5 Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
6 Department of Anatomical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Abolfazl Abbaszadeh
Department of Geriatric Medicine, Ziyaiyan Hospital, Tehran University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ATMPH.ATMPH_646_17

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Background: Immediate identification and treatment of patients at the risk of developing sepsis would contribute to a more efficient diagnosis. This study aimed to examine the effective determinants bringing about the rapid progression of this disease towards septic shock and severe sepsis. Materials and Methods: This study is a retrospective cross-sectional research on the patients, above 12 years, admitted to one of the hospitals in Tehran. It took 18 months to conduct this study that included merely patients with sepsis. Patients' cases were examined thoroughly, and eventually the progression of their diseases towards septic shock (low blood pressure despite adequate fluid intake) or severe sepsis (organ dysfunction) and related factors were investigated. Results: We included 230 patients, among whom 84 individuals developed septic shock and severe sepsis within 72 h. The Effective factors in the progression of their diseases were old age, high temperature, female sex, vascular catheter-related infections, low serum albumin, and diastolic pressure <52 (P = 0.025, 0.04, <0.001, 0.006, <0.001, and <0.001) respectively. Conclusion: A significant number of patients with sepsis developed septic shock and severe sepsis. Our study indicated that factors such as age, sex, low albumin, and low diastolic pressure play major roles in the progression of this disease in patients.


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