Annals of Tropical Medicine and Public Health
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Year : 2008  |  Volume : 1  |  Issue : 2  |  Page : 68-69

Isolated gonadotropin deficiency associated with empty sella

1 Department of Pharmacology, Kasturba Medical College, Mangalore 575 001, India
2 Department of Medicine, Kasturba Medical College, Mangalore 575 001, India

Correspondence Address:
Mukta N Chowta
Department of Pharmacology, Kasturba Medical College, Mangalore 575 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.50689

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Empty sella syndrome may be associated with abnormal pituitary function. Low levels of growth hormone (GH) are most common, but other pituitary hormones may also be deficient. Case Report : The patient was a 30-year-old male who presented with complaints of failure to attain puberty, break in voice, gynecomastia, marfanoid features, under developed genitalia, and testicular atrophy. He had eunuchoid body proportions with a height of 177 cm, an arm span of 183 cm, a lower segment of 101 cm, and a sitting height of 79 cm. There was no anosmia or midline defects. A computed tomography scan showed empty sella turcica. Magnetic resonance imaging of the brain showed a hypoplastic pituitary within empty sella turcica and cerebrospinal fluid (CSF) collection surrounding the gland. His laboratory investigations showed low luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone levels. The patient was treated with testosterone replacement and human chorionic gonadotropin (HCG). His condition improved after therapy except for persisting azoospermia. Conclusion: Uncommon presentation of isolated gonadotropin deficiency leading to delayed puberty due to pituitary cause.

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