Annals of Tropical Medicine and Public Health
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Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 74
QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis

1 Medical Science, Medical Center, Shantou, China
2 Department of Tropical Medicine, Hainan Medical University, China

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Date of Web Publication25-May-2015

How to cite this article:
Tin SS, Wiwanitkit V. QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis. Ann Trop Med Public Health 2015;8:74

How to cite this URL:
Tin SS, Wiwanitkit V. QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test in screening for latent tuberculosis in psoriasis. Ann Trop Med Public Health [serial online] 2015 [cited 2021 Jan 16];8:74. Available from:
Dear Sir,

The usefulness of QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis is interesting. The use of these two tests in the case of patients with some specific concomitant medical disorders should be discussed. Of several conditions, psoriasis is an interesting underlying problem to be considered. Although both QFT-GIT and TST for the screening of latent tuberculosis are widely assessed for their diagnostic properties, psoriasis is a complex immunologic disorder; therefore, it is not possible to project the results of other studies to a study population of psoriasis patients. Duman et al. concluded that "the cut-off point for TST positivity in psoriasis and PA patients should be re-evaluated, or other tests, such as the QFT-GIT, should be used." [1] The conclusions of Duman et al. are pertinent for only those patients with psoriasis. In fact, as an interferon-gamma release assay, QFT-GIT is approved for its efficacy in the diagnosis of latent tuberculosis. [2] However, it should be noted that many reports did not show QFT-GIT as having better efficacy than the standard TST. [3],[4] Finally, the cost-effectiveness of QFT-GIT should also be discussed. It seems that the higher cost of QFT-GIT might be a big obstacle for using this test in resource-limited settings where tuberculosis is usually endemic. [5] Nevertheless, there is not enough literature regarding the costs in case of psoriasis patients. In some cases, antitumor necrosis factor (anti-TNF) agents are used and in case of false negative TST, the cost will increase if the patient dies or if there is a need for tuberculosis treatment.

   References Top

Duman N, Ersoy-Evans S, Karadağ O, Aşçıoğlu S, Sener B, Kiraz S, et al. Screening for latent tuberculosis infection in psoriasis and psoriatic arthritis patients in a tuberculosis-endemic country: A comparison of the QuantiFERON ® -TB Gold In-Tube test and tuberculin skin test. Int J Dermatol 2014;53:1286-92.  Back to cited text no. 1
De Keyser E, De Keyser F, De Baets F. Tuberculin skin test versus interferon-gamma release assays for the diagnosis of tuberculosis infection. Acta Clin Belg 2014;69:358-66.  Back to cited text no. 2
Verhagen LM, Maes M, Villalba JA, d'Alessandro A, Rodriguez LP, España MF, et al. Agreement between QuantiFERON ® -TB Gold In-Tube and the tuberculin skin test and predictors of positive test results in Warao Amerindian pediatric tuberculosis contacts. BMC Infect Dis 2014;14:383.  Back to cited text no. 3
Rutherford ME, Nataprawira M, Yulita I, Apriani L, Maharani W, van Crevel R, et al. QuantiFERON ® -TB Gold In-Tube assay vs. tuberculin skin test in Indonesian children living with a tuberculosis case. Int J Tuberc Lung Dis 2012;16:496-502.   Back to cited text no. 4
Wiwanitkit V. Field QuantiFERON-TB gold test. Am J Infect Control 2011;39:447.  Back to cited text no. 5

Correspondence Address:
Prof. Sim Sai Tin
Medical Center, Shantou
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.157642

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